Propylene oxide assisted one-pot, tandem synthesis of substituted-1,3,4-oxadiazole-2(3H)-ones in water

被引：31

作者：

Yan, Xu ^{[1
]}

Zhou, Shuo ^{[1
]}

Wang, Yuanqiang ^{[1
]}

Ge, Zemei ^{[1
]}

Cheng, Tieming ^{[1
]}

Li, Runtao ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

TETRAHEDRON | 2012年 / 68卷 / 38期

基金：

中国国家自然科学基金;

关键词：

Substituted-1,3,4-oxadiazole-2(3H)-ones; One-pot; Tandem procedure; Propylene oxide; Environmentally friendly; MEDIATED SYNTHESIS; B INHIBITORS; DERIVATIVES; EFFICIENT; 1,3,4-OXADIAZOLES; ANALOGS; PHENYL; DESIGN; ACID;

D O I：

10.1016/j.tet.2012.07.004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It has been developed for the synthesis of substituted-1,3,4-oxadiazole-2(3H)-one derivatives via a novel one-pot, tandem procedure assisted by propylene oxide. The 5-substitued-1,3,4-oxadiazole-2(3H)-ones and 3,5-disubstitued-1,3,4-oxadiazole-2(3H)-ones were, respectively, obtained from three-component reaction of acylhydrazines, carbon disulfide, and propylene oxide, and four-component reaction of acylhydarazines, carbon disulfide, propylene oxide, and organic halides. The reactions were carried out using water as solvent in the presence of potassium phosphate to afford the expected products in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：7978 / 7983

页数：6

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