Prophylactic and Therapeutic Effects of a Subcutaneous Injection of Sesame Oil Against Iron-Induced Acute Renal Injury in Mice

被引：7
作者：
Li, Ya-Hui [1 ]
Chien, Se-Ping [2 ]
Chu, Pei-Yi [1 ]
Liu, Ming-Yie [1 ,3 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70428, Taiwan
[2] Tainan Univ Technol, Inst Living Sci, Tainan, Taiwan
[3] Natl Cheng Kung Univ, Sustainable Environm Res Ctr, Tainan 70101, Taiwan
来源：
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | 2012年 / 36卷 / 03期
关键词：
Iron intoxication; sesame oil; renal injury; mice; SODIUM FERRIC GLUCONATE; OXIDATIVE STRESS; LIPID-PEROXIDATION; INTRAVENOUS IRON; CECAL LIGATION; HEPATIC-INJURY; MEDICATION; RATS; HEMOCHROMATOSIS; OVERLOAD;
D O I：
10.1177/0148607111415530
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Background: Iron intoxication causes acute nephrotoxicity in animals and humans. Sesame oil, a healthful food, increases resistance to lipid peroxidation and protects against multiple organ injury in various animal models. The authors examined the prophylactic and therapeutic effects of a subcutaneous injection of sesame oil against iron-induced acute renal injury in mice. Methods: Iron intoxication in mice was induced with an intraperitoneal injection (2 mg/kg) of ferric-nitrilotriacetate (Fe-NTA). Various doses of sesame oil (0, 1, 2, and 4 mL/kg, subcutaneously) were given immediately after (prophylactic) or 30 minutes after (therapeutic) the Fe-NTA injection. Renal injury was assessed by the rise in serum blood urea nitrogen (BUN) and creatinine (CRE) levels 3 hours after the Fe-NTA injection. Results: One hour after the Fe-NTA injection, serum BUN and CRE levels were significantly higher in Fe-NTA-treated mice than in saline-treated controls; 3 and 6 hours after the Fe-NTA injection, they were dose-dependently and significantly lower in all sesame oil-treated groups than in the group treated only with Fe-NTA and saline. Conclusion: A subcutaneous injection of sesame oil had both prophylactic and therapeutic effects against iron-induced acute renal injury in mice. (JPEN J Parenter Enteral Nutr. 2012;36:344-348)
引用
收藏
页码：344 / 348
页数：5
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