Nickel-Catalyzed System for the Cross-Coupling of Alkenyl Methyl Ethers with Grignard Reagents under Mild Conditions

被引：20

作者：

Hostier, Thomas ^{[1
]}

Neouchy, Zeina ^{[1
]}

Ferey, Vincent ^{[1
,2
]}

Pardo, Domingo Gomez ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Res Univ, CNRS, Inst Chem Biol & Innovat CBI, Lab Chim Organ,UMR 8231,ESPCI Paris, 10 Rue Vauquelin, F-75231 Paris 05, France

[2] SANOFI, Chem & Biotechnol Dev, 371 Rue Prof Blayac, F-34184 Montpellier 04, France

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 07期

关键词：

ARYL ETHERS; BOND FORMATION; CARBON-OXYGEN; ALKYL-HALIDES; ACTIVATION; ANISOLES; NI; TRANSFORMATIONS;

D O I：

10.1021/acs.orglett.8b00313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed cross-coupling of alkenyl methyl ethers with Grignard reagents, under mild conditions, is described. These conditions allowed access to various stilbenes and heterocyclic stilbenic derivatives as well as to a potential anticancer agent DMU-212.

引用

页码：1815 / 1818

页数：4

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