One-Pot Synthesis of 4-Substituted 1H-[1,2,3]triazolo[4,5-c]quinolines Through CuO-Promoted Tandem Cyclization Reactions of (E)-3-(2-Bromoaryl)-1-arylprop-2-en-1-ones with Sodium Azide

被引：13

作者：

Li, Kangning ^{[1
,2
]}

Chen, Jinying ^{[1
,2
]}

Li, Jihui ^{[1
,2
]}

Chen, Yongxin ^{[1
,2
]}

Qu, Jinpeng ^{[1
,2
]}

Guo, Xin ^{[1
,2
]}

Chen, Chunxia ^{[1
,2
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Organ Chem, Lanzhou 730000, Peoples R China

[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 28期

基金：

美国国家科学基金会;

关键词：

Domino reactions; Nitrogen heterocycles; Copper; Azides; Cyclization; TERMINAL ACETYLENES; CLICK CHEMISTRY; ACID-CHLORIDES; CYCLOADDITION; 1,2,3-TRIAZOLES; DERIVATIVES; INHIBITORS; AMINATION; QUINOLINE;

D O I：

10.1002/ejoc.201300924

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient protocol for the synthesis of 4-substituted-1H-[1,2,3]triazolo[4,5-c]quinolines through a CuO-promoted tandem cyclization reaction has been developed. This method allows for the construction of two heterocyclic rings in a one-pot reaction of readily available (E)-3-(2-bromoaryl)-1-arylprop-2-en-1-ones and sodium azide without the addition of any additive. A series of triazole-fused N-heterocyclic compounds could be prepared in moderate to good yields.

引用

页码：6246 / 6248

页数：3

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