The Effects of Polypharmacy in Older Adults

被引：230
作者：
Hilmer, S. N. [1 ,2 ,3 ]
Gnjidic, D. [1 ,2 ,3 ]
机构：
[1] Royal N Shore Hosp, Dept Clin Pharmacol, St Leonards, NSW 2065, Australia
[2] Royal N Shore Hosp, Dept Aged Care & Rehabil, St Leonards, NSW 2065, Australia
[3] Univ Sydney, Fac Med, No Clin Sch, Sydney, NSW 2006, Australia
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 85卷 / 01期
关键词：
LOWER-EXTREMITY FUNCTION; DRUG-DRUG INTERACTIONS; PHYSICAL PERFORMANCE; FUNCTIONAL OUTCOMES; ELDERLY POPULATION; NURSING-HOME; PEOPLE; FALLS; RISK; AGE;
D O I：
10.1038/clpt.2008.224
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
An assessment of the safety and efficacy of multiple medications in older adults requires clinically relevant objective outcomes and pharmacological measures of medication exposure. Important outcomes include geriatric syndromes and objective measures of physical function. Measurements of medication exposure have evolved from merely counting the drugs to a consideration of pharmacologic principles such as drug class, dose response, and maximal effect. Emerging evidence regarding the effects of cumulative medication exposure on functions critical for independence may provide guidance for prescribers.
引用
收藏
页码：86 / 88
页数：3
相关论文
共 50 条
  • [31] Health Outcomes Associated with Polypharmacy in Community-Dwelling Older Adults: A Systematic Review
    Fried, Terri R.
    O'Leary, John
    Towle, Virginia
    Goldstein, Mary K.
    Trentalange, Mark
    Martin, Deanna K.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2014, 62 (12) : 2261 - 2272
  • [32] Profiles of polypharmacy in older adults and medication associations with signs of aspiration
    Pu, Dai
    Wong, Michael C. H.
    Yiu, Edwin M. L.
    Chan, Karen M. K.
    EXPERT REVIEW OF CLINICAL PHARMACOLOGY, 2021, 14 (05) : 643 - 649
  • [33] An update on the clinical consequences of polypharmacy in older adults: a narrative review
    Wastesson, Jonas W.
    Morin, Lucas
    Tan, Edwin C. K.
    Johnell, Kristina
    EXPERT OPINION ON DRUG SAFETY, 2018, 17 (12) : 1185 - 1196
  • [34] Polypharmacy in Older Adults: Practical Applications Alongside a Patient Case
    Nguyen, Timothy
    Wong, Elaine
    Ciummo, Francesco
    JNP- THE JOURNAL FOR NURSE PRACTITIONERS, 2020, 16 (03): : 205 - 209
  • [35] Polypharmacy Management in the Older Adults: A Scoping Review of Available Interventions
    Kurczewska-Michalak, M.
    Lewek, P.
    Jankowska-Polanska, B.
    Giardini, A.
    Granata, N.
    Maffoni, M.
    Costa, E.
    Midao, L.
    Kardas, P.
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [36] Polypharmacy and excessive polypharmacy in octogenarians and older acutely hospitalized patients
    Strehblow, Christoph
    Smeikal, Michael
    Fasching, Peter
    WIENER KLINISCHE WOCHENSCHRIFT, 2014, 126 (7-8) : 195 - 200
  • [37] Polypharmacy and medicine regimens in older adults in residential aged care
    Page, Amy Theresa
    Potter, Kathleen
    Naganathan, Vasi
    Hilmer, Sarah
    McLachlan, Andrew J.
    Lindley, Richard, I
    Coman, Tracy
    Mangin, D.
    Etherton-Beer, Christopher
    ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2023, 105
  • [38] Opioids and Other Central Nervous System-Active Polypharmacy in Older Adults in the United States
    Gerlach, Lauren B.
    Olfson, Mark
    Kales, Helen C.
    Maust, Donovan T.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2017, 65 (09) : 2052 - 2056
  • [39] Use of potentially inappropriate medication and polypharmacy in older adults: a repeated cross-sectional study
    Thorell, Kristine
    Midlov, Patrik
    Fastbom, Johan
    Halling, Anders
    BMC GERIATRICS, 2020, 20 (01)
  • [40] Polypharmacy prevalence in older adults seen in United States physician offices from 2009 to 2016
    Young, Eric H.
    Pan, Samantha
    Yap, Alex G.
    Reveles, Kelly R.
    Bhakta, Kajal
    PLOS ONE, 2021, 16 (08):
12345