The Effects of Polypharmacy in Older Adults

被引：229
作者：
Hilmer, S. N. [1 ,2 ,3 ]
Gnjidic, D. [1 ,2 ,3 ]
机构：
[1] Royal N Shore Hosp, Dept Clin Pharmacol, St Leonards, NSW 2065, Australia
[2] Royal N Shore Hosp, Dept Aged Care & Rehabil, St Leonards, NSW 2065, Australia
[3] Univ Sydney, Fac Med, No Clin Sch, Sydney, NSW 2006, Australia
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 85卷 / 01期
关键词：
LOWER-EXTREMITY FUNCTION; DRUG-DRUG INTERACTIONS; PHYSICAL PERFORMANCE; FUNCTIONAL OUTCOMES; ELDERLY POPULATION; NURSING-HOME; PEOPLE; FALLS; RISK; AGE;
D O I：
10.1038/clpt.2008.224
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
An assessment of the safety and efficacy of multiple medications in older adults requires clinically relevant objective outcomes and pharmacological measures of medication exposure. Important outcomes include geriatric syndromes and objective measures of physical function. Measurements of medication exposure have evolved from merely counting the drugs to a consideration of pharmacologic principles such as drug class, dose response, and maximal effect. Emerging evidence regarding the effects of cumulative medication exposure on functions critical for independence may provide guidance for prescribers.
引用
收藏
页码：86 / 88
页数：3
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