Mitochondrial DNA in inflammation and immunity

被引：604

作者：

Riley, Joel S. ^{[1
,2
]}

Tait, Stephen W. G. ^{[1
,2
]}

机构：

[1] Canc Res UK Beatson Inst, Glasgow, Lanark, Scotland

[2] Univ Glasgow, Inst Canc Sci, Glasgow, Lanark, Scotland

来源：

EMBO REPORTS | 2020年 / 21卷 / 04期

关键词：

cell death; inflammation; immunity; mitochondria; mtDNA; CYCLIC GMP-AMP; AICARDI-GOUTIERES-SYNDROME; PERMEABILITY TRANSITION PORE; PARKIN-DEFICIENT MICE; CYTOCHROME-C RELEASE; TOLL-LIKE RECEPTORS; EXONUCLEASE TREX1; I INTERFERONS; CUTTING EDGE; CPG-DNA;

D O I：

10.15252/embr.201949799

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation. Despite this seemingly symbiotic relationship, mitochondria harbour within them a potent agonist of innate immunity: their own genome. Release of mitochondrial DNA into the cytoplasm and out into the extracellular milieu activates a plethora of different pattern recognition receptors and innate immune responses, including cGAS-STING, TLR9 and inflammasome formation leading to, among others, robust type I interferon responses. In this Review, we discuss how mtDNA can be released from the mitochondria, the various inflammatory pathways triggered by mtDNA release and its myriad biological consequences for health and disease.

引用

页数：17

共 207 条

[1] Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING [J].

Aarreberg, Lauren D. ;

Esser-Nobis, Katharina ;

Driscoll, Connor ;

Shuvarikov, Andrey ;

Roby, Justin A. ;

Gale, Michael, Jr. .

MOLECULAR CELL, 2019, 74 (04) :801-+

[2] Mycobacterium tuberculosis virulence correlates with mitochondrial cytochrome c release in infected macrophages [J].

Abarca-Rojano, E ;

Rosas-Medina, P ;

Zamudio-Cortéz, P ;

Mondragón-Flores, R ;

Sánchez-García, FJ .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2003, 58 (04) :419-427

[3] A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe [J].

Abbas, N ;

Lücking, CB ;

Ricard, S ;

Dürr, A ;

Bonifati, V ;

De Michele, G ;

Bouley, S ;

Vaughan, JR ;

Gasser, T ;

Marconi, R ;

Broussolle, E ;

Brefel-Courbon, C ;

Harhangi, BS ;

Oostra, AB ;

Fabrizio, E ;

Böhme, GA ;

Pradier, L ;

Wood, NW ;

Filla, A ;

Meco, G ;

Denefle, P ;

Agid, Y ;

Brice, A .

HUMAN MOLECULAR GENETICS, 1999, 8 (04) :567-574

[4] Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF-κB Activation through TBK1 [J].

Abe, Takayuki ;

Barber, Glen N. .

JOURNAL OF VIROLOGY, 2014, 88 (10) :5328-5341

[5] TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner [J].

Ablasser, Andrea ;

Hemmerling, Inga ;

Schmid-Burgk, Jonathan L. ;

Behrendt, Rayk ;

Roers, Axel ;

Hornung, Veit .

JOURNAL OF IMMUNOLOGY, 2014, 192 (12) :5993-5997

[6] Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis [J].

Ader, Nicholas R. ;

Hoffmann, Patrick C. ;

Ganeva, Iva ;

Borgeaud, Alicia C. ;

Wang, Chunxin ;

Youle, Richard J. ;

Kukulski, Wanda .

ELIFE, 2019, 8

[7] Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis [J].

Afonso, Marta B. ;

Rodrigues, Pedro M. ;

Carvalho, Tania ;

Caridade, Marta ;

Borralho, Paula ;

Cortez-Pinto, Helena ;

Castro, Rui E. ;

Rodrigues, Cecilia M. P. .

CLINICAL SCIENCE, 2015, 129 (08) :721-739

[8] Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection [J].

Aguirre, Sebastian ;

Luthra, Priya ;

Sanchez-Aparicio, Maria T. ;

Maestre, Ana M. ;

Patel, Jenish ;

Lamothe, Francise ;

Fredericks, Anthony C. ;

Tripathi, Shashank ;

Zhu, Tongtong ;

Pintado-Silva, Jessica ;

Webb, Laurence G. ;

Bernal-Rubio, Dabeiba ;

Solovyov, Alexander ;

Greenbaum, Benjamin ;

Simon, Viviana ;

Basler, Christopher F. ;

Mulder, Lubbertus C. F. ;

Garcia-Sastre, Adolfo ;

Fernandez-Sesma, Ana .

NATURE MICROBIOLOGY, 2017, 2 (05)

[9] DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING [J].

Aguirre, Sebastian ;

Maestre, Ana M. ;

Pagni, Sarah ;

Patel, Jenish R. ;

Savage, Timothy ;

Gutman, Delia ;

Maringer, Kevin ;

Bernal-Rubio, Dabeiba ;

Shabman, Reed S. ;

Simon, Viviana ;

Rodriguez-Madoz, Juan R. ;

Mulder, Lubbertus C. F. ;

Barber, Glen N. ;

Fernandez-Sesma, Ana .

PLOS PATHOGENS, 2012, 8 (10)

[10]

Ahmad-Nejad P, 2002, EUR J IMMUNOL, V32, P1958, DOI 10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO

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