Vinculin, cell mechanics and tumour cell invasion

被引：73
作者：
Goldmann, Wolfgang H. [1 ]
Auernheimer, Vera [1 ]
Thievessen, Ingo [1 ]
Fabry, Ben [1 ]
机构：
[1] Univ Erlangen Nurnberg, Ctr Med Phys & Technol, Biophys Grp, D-91052 Erlangen, Germany
来源：
CELL BIOLOGY INTERNATIONAL | 2013年 / 37卷 / 05期
关键词：
vinculin; focal adhesions; adherence junctions; cancer; cell mechanics; ECM; 2D and 3D environment; FOCAL ADHESION FORMATION; CARCINOMA-CELLS; ALPHA-ACTININ; INTRAMOLECULAR ASSOCIATION; TYROSINE PHOSPHORYLATION; PROTEIN VINCULIN; MATRIX ADHESION; BINDING-SITES; F9; CELLS; TALIN;
D O I：
10.1002/cbin.10064
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.
引用
收藏
页码：397 / 405
页数：9
相关论文
共 110 条
  • [21] TARGETED DISRUPTION OF VINCULIN GENES IN F9 AND EMBRYONIC STEM-CELLS CHANGES CELL MORPHOLOGY, ADHESION, AND LOCOMOTION
    COLL, JL
    BENZEEV, A
    EZZELL, RM
    FERNANDEZ, JLR
    BARIBAULT, H
    OSHIMA, RG
    ADAMSON, ED
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) : 9161 - 9165
  • [22] Coussen F, 2002, J CELL SCI, V115, P2581
  • [23] AN INTERACTION BETWEEN ZYXIN AND ALPHA-ACTININ
    CRAWFORD, AW
    MICHELSEN, JW
    BECKERLE, MC
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 116 (06) : 1381 - 1393
  • [24] Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
    Critchley, DR
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 : 831 - 836
  • [25] Focal adhesions - the cytoskeletal connection
    Critchley, DR
    [J]. CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (01) : 133 - 139
  • [26] Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
    DeMali, KA
    Barlow, CA
    Burridge, K
    [J]. JOURNAL OF CELL BIOLOGY, 2002, 159 (05) : 881 - 891
  • [27] Localized mechanical stress induces time-dependent actin cytoskeletal remodeling and stiffening in cultured airway smooth muscle cells
    Deng, LH
    Fairbank, NJ
    Fabry, B
    Smith, PG
    Maksym, GN
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 287 (02): : C440 - C448
  • [28] Comparing mechano-transduction in fibroblasts deficient of focal adhesion proteins
    Dey, Tuli
    Mann, Melanie C.
    Goldmann, Wolfgang H.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 413 (04) : 541 - 544
  • [29] Direct evidence of vinculin tail-lipid membrane interaction in beta-sheet conformation
    Diez, Gerold
    List, Felix
    Smith, James
    Ziegler, Wolfgang H.
    Goldmann, Wolfgang H.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 373 (01) : 69 - 73
  • [30] Anchorage of Vinculin to Lipid Membranes Influences Cell Mechanical Properties
    Diez, Gerold
    Kollmannsberger, Philip
    Mierke, Claudia T.
    Koch, Thorsten M.
    Vali, Hojatollah
    Fabry, Ben
    Goldmann, Wolfgang H.
    [J]. BIOPHYSICAL JOURNAL, 2009, 97 (12) : 3105 - 3112
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