Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats

被引：32
作者：
Liang, Junbo [1 ]
Chen, Haixiao [1 ]
Pan, Weibo [1 ]
Xu, Chunli [1 ]
机构：
[1] Taizhou Hosp Zhejiang Prov, Dept Orthoped, Taizhou 317000, Zhejiang, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2012年 / 5卷 / 06期
关键词：
puerarin; diabetic osteoporosis; caspase-3; bone mineral density; VERTEBRAL FRACTURES; BONE-FORMATION; MELLITUS; OSTEOPOROSIS; ACTIVATION; PI3K/AKT; DISEASE; KINASE; CELLS; FATE;
D O I：
10.3892/mmr.2012.854
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to investigate the protective effect of puerarin on attenuating caspase-3 expression in osteoblasts of streptozotocin-induced diabetic rats and the possible mechanisms involved. Diabetic rats were treated with a puerarin injection of 100 mg/kg/day. After 6 weeks, the bone mineral density, pathological changes and expression of caspase-3 were observed. The bone mineral density in the diabetic rats was significantly lower compared to the control group, while osteoblast numbers in the cortical bone were significantly reduced, and new bone formation in the diabetic rats was rare. Caspase-3 expression in the osteoblasts of diabetic rats increased compared to the rats in the control group. These pathological changes were improved and caspase-3 expression decreased in the puerarin-treated rats compared to the diabetic rats (P<0.01). High glucose levels affect bone metabolism and increase caspase-3 expression in osteoblasts, and thus lead to diabetic osteoporosis. Puerarin may play a protective role in diabetic osteoporosis via the reduction of caspase-3 expression.
引用
收藏
页码：1419 / 1422
页数：4
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