Chronic fatigue syndrome: A new disorder?

被引：9

作者：

de Korwin, J. -D. ^{[1
]}

Chiche, L. ^{[2
]}

Banovic, I. ^{[3
]}

Ghali, A. ^{[4
]}

Delliaux, S. ^{[5
]}

Authier, F. -J. ^{[6
]}

Cozon, G. ^{[7
]}

Hatron, P. -Y. ^{[8
]}

Fornasieri, I. ^{[9
]}

Morinet, F. ^{[10
]}

机构：

[1] Univ Lorraine, Hop Brabois BPC, Dept Med Interne & Immunol Clin, Fac Med,CHU Nancy, Rue Morvan, F-54511 Vandoeuvre Les Nancy, France

[2] Hop Europeen, Serv Med Interne, 6 Rue Desiree Clary, F-13003 Marseille, France

[3] UFR Sci Homme & Soc, EA 4700, UPRES PSY NCA, Rue Lavoisier, F-76821 Mont St Aignan, France

[4] Aix Marseille Univ, Hop Nord, AP HM,MD,DS ACI,UMR 2, Pole Cardiovasc & Thorac,Lab Physiol Resp Explora, F-13915 Marseille, France

[5] CHU Angers, Serv Med Interne, 4 Rue Larrey, F-49933 Angers 09, France

[6] CHU Henri Mondor, AP HP, Ctr Reference Malad Neuromusculaires,Fac Med Cret, DHU Pepsy,Inserm,U955,Eq Biol Syst Neuromusculair, F-94000 Creteil, France

[7] Univ Claude Bernard Lyon 1, UFR Med Lyon Est, Hop Edouard Herriot, Immunol Clin, Pavillon F, F-69437 Lyon 03, France

[8] CHU Huriez, Ctr Natl Reference Malad Rares, Serv Med Interne, Pl Verdun, F-59037 Lille, France

[9] Univ Strasbourg, Fac Psychol, 12 Rue Goethe, F-67000 Strasbourg, France

[10] Univ Paris Diderot Paris 7, Hop St Louis, AP HP, Pole Biol Pathol Physiol, 1 Ave Vellefaux, F-75010 Paris, France

来源：

REVUE DE MEDECINE INTERNE | 2016年 / 37卷 / 12期

关键词：

Chronic fatigue syndrome; Myalgic encephalomyelitis; Systemic exertion intolerance disease; Infections; Inflammation; Immunologic disorders; Autoimmune diseases; Fibromyalgia; OF-HEALTH PATHWAYS; FIBROMYALGIA; MUSCLE; ENCEPHALOMYELITIS; PREVALENCE; DEPRESSION; MANAGEMENT; CELLS; WOMEN;

D O I：

10.1016/j.revmed.2016.05.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

More than 30 years after its individualization, chronic fatigue syndrome (CFS) remains a debilitating condition for the patient and a confusing one to the physicians, both because of diagnostic difficulties and poorly codified management. Despite the numerous work carried out, its pathophysiology remains unclear,, but a multifactorial origin is suggested with triggering (infections) and maintenance (psychological) factors as well as the persistence of inflammatory (low grade inflammation, microglial activation...), immunologic (decrease of NI( cells, abnormal cytokine production, reactivity to a variety of allergens, role of estrogens...) and muscular (mitochondrial dysfunction and failure of bioenergetic performance) abnormalities at the origin of multiple dysfunctions (endocrine, neuromuscular, cardiovascular, digestive...). The complexity of the problem and the sometimes contradictory results of available studies performed so far are at the origin of different pathophysiological and diagnostic concepts. Based on a rigorous analysis of scientific data, the new American concept of Systemic Disease Exertion Intolerance proposed in 2015 simplifies the diagnostic approach and breaks with the past and terminologies (CFS and myalgic encephalomyelitis). It is still too early to distinguish a new disease, but this initiative is a strong signal to intensify the recognition and management of patients with CFS and stimulate research. (C) 2016 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS: All rights reserved.

引用

页码：811 / 819

页数：9