The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

被引：170

作者：

Backer, Jonathan M. ^{[1
,2
]}

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

BIOCHEMICAL JOURNAL | 2016年 / 473卷

基金：

美国国家卫生研究院;

关键词：

autophagy; Class III phosphoinositide 3-kinase; endocytosis; phosphoinositide; 3-kinase; phosphorylation/dephosphorylation; Vps34; PHOSPHATIDYLINOSITOL 3-PHOSPHATE FORMATION; BECLIN 1-DEPENDENT AUTOPHAGY; HUMAN BREAST-CANCER; T-CELL HOMEOSTASIS; PROTEIN SORTING 34; BCL-X-L; INHIBITS AUTOPHAGY; TUMOR-SUPPRESSOR; PHOSPHOLIPASE-D; LIPID KINASE;

D O I：

10.1042/BCJ20160170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.

引用

页码：2251 / 2271

页数：21

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