HIF2 Inhibitor Joins the Kidney Cancer Armamentarium

被引：16

作者：

Kaelin, William G., Jr. ^{[1
]}

机构：

[1] Harvard Med Sch, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2018年 / 36卷 / 09期

基金：

美国国家卫生研究院;

关键词：

RENAL-CELL CARCINOMA; HYPOXIA-INDUCIBLE FACTOR-2; LINDAU TUMOR-SUPPRESSOR; PAS-B DOMAIN; TRANSCRIPTION FACTOR; HIF2-ALPHA; INACTIVATION; HIF-2-ALPHA; ANTAGONIST; MICE;

D O I：

10.1200/JCO.2017.77.5254

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：908 / +

页数：5

共 32 条

[11] Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo
Kim, William Y.
Safran, Michal
Buckley, Marshall R. M.
Ebert, Benjamin L.
Glickman, Jonathan
Bosenberg, Marcus
Regan, Meredith
Kaelin, William G., Jr.
[J]. EMBO JOURNAL, 2006, 25 (19) : 4650 - 4662
[12] Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth
Kondo, K
Kim, WY
Lechpammer, M
Kaelin, WG
[J]. PLOS BIOLOGY, 2003, 1 (03): : 439 - 444
[13] Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
Kondo, K
Klco, J
Nakamura, E
Lechpammer, M
Kaelin, WG
[J]. CANCER CELL, 2002, 1 (03) : 237 - 246
[14] Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
Krieg, M
Haas, R
Brauch, H
Acker, T
Flamme, I
Plate, KH
[J]. ONCOGENE, 2000, 19 (48) : 5435 - 5443
[15] HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
Mandriota, SJ
Turner, KJ
Davies, DR
Murray, PG
Morgan, NV
Sowter, HM
Wykoff, CC
Maher, ER
Harris, AL
Ratcliffe, PJ
Maxwell, PH
[J]. CANCER CELL, 2002, 1 (05) : 459 - 468
[16] The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
Maranchie, JK
Vasselli, JR
Riss, J
Bonifacino, JS
Linehan, WM
Klausner, RD
[J]. CANCER CELL, 2002, 1 (03) : 247 - 255
[17] The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, PH
Wiesener, MS
Chang, GW
Clifford, SC
Vaux, EC
Cockman, ME
Wykoff, CC
Pugh, CW
Maher, ER
Ratcliffe, PJ
[J]. NATURE, 1999, 399 (6733) : 271 - 275
[18] Evolution of Circulating Tumor DNA Profile from First-line to Subsequent Therapy in Metastatic Renal Cell Carcinoma
Pal, Sumanta K.
Sonpavde, Guru
Agarwal, Neeraj
Vogelzang, Nicholas J.
Srinivas, Sandy
Haas, Naomi B.
Signoretti, Sabina
McGregor, Bradley A.
Jones, Jeremy
Lanman, Richard B.
Banks, Kimberly C.
Choueiri, Toni K.
[J]. EUROPEAN UROLOGY, 2017, 72 (04) : 557 - 564
[19] Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
Purdue, Mark P.
Johansson, Mattias
Zelenika, Diana
Toro, Jorge R.
Scelo, Ghislaine
Moore, Lee E.
Prokhortchouk, Egor
Wu, Xifeng
Kiemeney, Lambertus A.
Gaborieau, Valerie
Jacobs, Kevin B.
Chow, Wong-Ho
Zaridze, David
Matveev, Vsevolod
Lubinski, Jan
Trubicka, Joanna
Szeszenia-Dabrowska, Neonila
Lissowska, Jolanta
Rudnai, Peter
Fabianova, Eleonora
Bucur, Alexandru
Bencko, Vladimir
Foretova, Lenka
Janout, Vladimir
Boffetta, Paolo
Colt, Joanne S.
Davis, Faith G.
Schwartz, Kendra L.
Banks, Rosamonde E.
Selby, Peter J.
Harnden, Patricia
Berg, Christine D.
Hsing, Ann W.
Grubb, Robert L., III
Boeing, Heiner
Vineis, Paolo
Clavel-Chapelon, Francoise
Palli, Domenico
Tumino, Rosario
Krogh, Vittorio
Panico, Salvatore
Duell, Eric J.
Quiros, Jose Ramon
Sanchez, Maria-Jose
Navarro, Carmen
Ardanaz, Eva
Dorronsoro, Miren
Khaw, Kay-Tee
Allen, Naomi E.
Bueno-de-Mesquita, H. Bas
[J]. NATURE GENETICS, 2011, 43 (01) : 60 - U83
[20] Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
Rankin, E. B.
Rha, J.
Unger, T. L.
Wu, C. H.
Shutt, H. P.
Johnson, R. S.
Simon, M. C.
Keith, B.
Haase, V. H.
[J]. ONCOGENE, 2008, 27 (40) : 5354 - 5358

← 1 2 3 4 →