Coding potential of UL/b′ from the initial source of rhesus cytomegalovirus Strain 68-1

被引：12

作者：

Gill, Rachel B. ^{[1
]}

Bowman, J. Jason ^{[1
]}

Krogmann, Tammy ^{[1
]}

Wollenberg, Kurt ^{[2
]}

Asher, David M. ^{[3
]}

Cohen, Jeffrey I. ^{[1
]}

机构：

[1] NIH, Med Virol Sect, Infect Dis Lab, Bethesda, MD 20892 USA

[2] NIH, Bioinformat & Computat Biosci Branch, Bethesda, MD 20892 USA

[3] US FDA, Lab Bacterial & Transmissible Spongiform Encephal, Div Emerging & Transfus Transmitted Dis, Rockville, MD 20852 USA

来源：

VIROLOGY | 2013年 / 447卷 / 1-2期

关键词：

Human cytomegalovirus; Rhesus cytomegalovirus; Cercopithecine herpesvirus: macacine herpesvirus 3; Cynomolgus macaque cytomegalovirus; UL/b '; ENDOTHELIAL-CELLS; ANTIBODY-RESPONSE; COMPLEX; ENCODES; GENES; REPLICATION; INFECTION; SEQUENCE; MODEL; ENTRY;

D O I：

10.1016/j.virol.2013.08.026

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rhesus cytomegalovirus (RhCMV) 68-1 is the prototypic strain of RhCMV that has been used for pathogenesis and vaccine development. We determined the complete sequence of the RhCMV 68-1 UL/b' region directly from the original urine from which RhCMV 68-1 was isolated in 1968, and compared it to other RhCMVs. The laboratory passaged RhCMV 68-1 has inversions, deletions, and stop codons in UL/b' that are absent in the original isolate and other low passage RhCMV isolates. Fourteen of the 17 open reading frames (ORFs) in 68-1 UL/b' in the original isolate share >95% amino acid identity with low passage RhCMV. The original isolate retains 6 ORFs that encode alpha-chemokine-like proteins, including RhUL146 and RhUL146b that share only 92% and 81% amino acid identity, respectively, with a contemporary low passage RhCMV isolate. Identification of the original RhCMV 68-1 UL/b' sequence is important for using RhCMV 68-1 in pathogenesis and vaccine studies. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：208 / 212

页数：5

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