How Do Channel- and Pore-Forming Helical Peptides Interact with Lipid Membranes and How does this Account for their Antimicrobial Activity?

被引：17
|
作者：
Duclohier, Herve [1 ]
机构：
[1] Univ Rennes, CNRS, Interact Cellulaires & Mol, UMR, F-35042 Rennes, France
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 04期
关键词：
channel-forming peptides; defense peptides; amphipathicity; lipid composition; cellular targets; planar lipid bilayers; conductances;
D O I：
10.2174/1389557023405963
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Animals and plants defend themselves against pathogenic micro-organisms by the rapid mobilization of polycationic helical amphipathic peptides. Interactions with membranes induce optimal orientation and mutual structural changes, allowing for example to form transbilayer ion channels or pores whose properties are compared in this review. Physicochemical studies of peptide-lipid interactions provide attractive approaches for drug design.
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收藏
页码：331 / 342
页数：12
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