Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines

被引：25

作者：

Lall, Namrita ^{[1
]}

Kishore, Navneet ^{[1
]}

Binneman, Brigitte ^{[1
]}

Twilley, Danielle ^{[1
]}

van de Venter, Maryna ^{[2
]}

du Plessis-Stoman, Debbie ^{[2
]}

Boukes, Gerhardt ^{[2
]}

Hussein, Ahmed ^{[1
,3
]}

机构：

[1] Univ Pretoria, Dept Plant Sci, ZA-0002 Pretoria, South Africa

[2] Nelson Mandela Metropolitan Univ, Dept Biochem & Microbiol, ZA-6031 Port Elizabeth, South Africa

[3] Univ Western Cape, Dept Chem, ZA-7535 Cape Town, South Africa

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

Foeniculum vulgare; cytotoxicity; 4-methoxycinnamyl alcohol; cell cycle analysis; DNA fragmentation;

D O I：

10.1080/14786419.2014.999058

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study was carried out to determine the cytotoxic effect of seven plant extracts and the isolated compounds - syringin and 4-methoxycinnamyl alcohol - on cancerous and non-cancerous cells. The ethanol extract of Foeniculum vulgare was found to exhibit the most significant toxicity with an IC50 value of 19.97g/mL on HeLa cells. Bioassay-guided fractionation led to the isolation of two compounds, syringin (1) and 4-methoxycinnamyl alcohol (2). Both compounds showed toxicity against MCF-7, HeLa and DU145 cancer cell line. The results showed that compound 2 showed high toxicity against all the cancer cell lines with IC50 values of 14.24, 7.82 and 22.10g/mL, respectively. 4-Methoxycinnamyl alcohol also showed no apoptotic effect in cell cycle analysis after 48h at a concentration of 10g/mL. However, DNA fragmentation study revealed that necrosis took place at a concentration of 10g/mL after 48h exposure.

引用

页码：1752 / 1756

页数：5

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