Diversity within the pRb pathway: is there a code of conduct?

被引：76
作者：
Munro, S. [1 ]
Carr, S. M. [1 ]
La Thangue, N. B. [1 ]
机构：
[1] Univ Oxford, Canc Biol Lab, Dept Oncol, Div Med Sci, Oxford OX3 7DQ, England
来源：
ONCOGENE | 2012年 / 31卷 / 40期
关键词：
pRb; E2F-1; phosphorylation; acetylation; methylation; RETINOBLASTOMA TUMOR-SUPPRESSOR; CYCLIN-DEPENDENT KINASES; DNA-DAMAGE; CELL-CYCLE; LYSINE METHYLATION; KERATINOCYTE DIFFERENTIATION; E2F1-INDUCED APOPTOSIS; HISTONE METHYLATION; DOCKING SITE; PROTEIN PRB;
D O I：
10.1038/onc.2011.603
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb with the ability to function in diverse physiological settings. Oncogene (2012) 31, 4343-4352; doi: 10.1038/onc.2011.603; published online 16 January 2012
引用
收藏
页码：4343 / 4352
页数：10
相关论文
共 94 条
[1]  
Adams PD, 1999, MOL CELL BIOL, V19, P1068
[2]   Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks [J].
Adams, PD .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2001, 1471 (03) :M123-M133
[3]   Protein Arginine Methylation in Mammals: Who, What, and Why [J].
Bedford, Mark T. ;
Clarke, Steven G. .
MOLECULAR CELL, 2009, 33 (01) :1-13
[4]  
Blattner C, 1999, MOL CELL BIOL, V19, P3704
[5]   MBT domain proteins in development and disease [J].
Bonasio, Roberto ;
Lecona, Emilio ;
Reinberg, Danny .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2010, 21 (02) :221-230
[6]   Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex [J].
Brown, Mark A. ;
Sims, Robert J., III ;
Gottlieb, Paul D. ;
Tucker, Philip W. .
MOLECULAR CANCER, 2006, 5 (1)
[7]   Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein [J].
Campanero, MR ;
Flemington, EK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2221-2226
[8]   Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein [J].
Carr, Simon M. ;
Munro, Shonagh ;
Kessler, Benedikt ;
Oppermann, Udo ;
La Thangue, Nicholas B. .
EMBO JOURNAL, 2011, 30 (02) :317-327
[9]   Acetylation control of the retinoblastoma tumour-suppressor protein [J].
Chan, HM ;
Krstic-Demonacos, M ;
Smith, L ;
Demonacos, C ;
La Thangue, NB .
NATURE CELL BIOLOGY, 2001, 3 (07) :667-674
[10]   Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein [J].
Chan, HM ;
Smith, L ;
La Thangue, NB .
ONCOGENE, 2001, 20 (43) :6152-6163
12345678910