Glucocorticoid-Induced Osteoporosis and Osteonecrosis

被引:338
作者
Weinstein, Robert S. [1 ,2 ]
机构
[1] Univ Arkansas Med Sci, Dept Internal Med, Ctr Osteoporosis & Metab Bone Dis, Div Endocrinol & Metab, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA
基金
美国国家卫生研究院;
关键词
Glucocorticoid-induced apoptosis; Osteoblasts; Osteocytes; Osteoclasts; Bone vascularity; Bisphosphonates; Teriparatide; Denosumab; BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; VERTEBRAL FRACTURE; FEMORAL-HEAD; AVASCULAR NECROSIS; HIGH PREVALENCE; DOUBLE-BLIND; ALENDRONATE; APOPTOSIS; PREVENTION;
D O I
10.1016/j.ecl.2012.04.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Glucocorticoid administration is the most common cause of secondary osteoporosis and the leading cause of nontraumatic osteonecrosis. In patients receiving long-term therapy, glucocorticoids induce fractures in 30% to 50% and osteonecrosis in 9% to 40%. This article reviews glucocorticoid-induced osteoporosis and osteonecrosis, addressing the risk factors, pathogenesis, evaluation, treatment, and uncertainties in the clinical management of these disorders.
引用
收藏
页码:595 / +
页数:18
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