Glucocorticoid-Induced Osteoporosis and Osteonecrosis

被引：338

作者：

Weinstein, Robert S. ^{[1
,2
]}

机构：

[1] Univ Arkansas Med Sci, Dept Internal Med, Ctr Osteoporosis & Metab Bone Dis, Div Endocrinol & Metab, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Glucocorticoid-induced apoptosis; Osteoblasts; Osteocytes; Osteoclasts; Bone vascularity; Bisphosphonates; Teriparatide; Denosumab; BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; VERTEBRAL FRACTURE; FEMORAL-HEAD; AVASCULAR NECROSIS; HIGH PREVALENCE; DOUBLE-BLIND; ALENDRONATE; APOPTOSIS; PREVENTION;

D O I：

10.1016/j.ecl.2012.04.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glucocorticoid administration is the most common cause of secondary osteoporosis and the leading cause of nontraumatic osteonecrosis. In patients receiving long-term therapy, glucocorticoids induce fractures in 30% to 50% and osteonecrosis in 9% to 40%. This article reviews glucocorticoid-induced osteoporosis and osteonecrosis, addressing the risk factors, pathogenesis, evaluation, treatment, and uncertainties in the clinical management of these disorders.

引用

页码：595 / +

页数：18

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