Coupling across a DNA helical turn yields a hybrid DNA/organic catenane doubly tailed with functional termini

被引：45

作者：

Liu, Yu ^{[1
]}

Kuzuya, Akinori ^{[1
]}

Sha, Ruojie ^{[1
]}

Guillaume, Johan ^{[1
]}

Wang, Risheng ^{[1
]}

Canary, James W. ^{[1
]}

Seeman, Nadrian C. ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 33期

关键词：

D O I：

10.1021/ja8041096

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

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页码：10882 / +

页数：3

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