Three-component synthesis of 5:6 and 6:6 fused pyrimidines using KF-alumina as a catalyst

被引：22

作者：

Mizar, Pushpak ^{[1
]}

Myrboh, Bekington ^{[1
]}

机构：

[1] N Eastern Hill University, Dept Chem, Shillong 793022, Meghalaya, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 36期

关键词：

D O I：

10.1016/j.tetlet.2008.06.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of fused pyrimidine derivatives were synthesized by the three-component reaction of an aryl aldehyde, urea, or guanidine in ethyl alcohol/dioxane in presence of 1-methyl-1H-pyrrol-2(3H)-one 1, 1-methylpiperidin-2-one 2, 1-methylindolin-2-one 3, or 1,3-dimethyl-dihydropyrimidine-2,4-dione 9 at 80 degrees C catalyzed by KF-Al2O3. For example, when 1-methyl-1H-pyrrol-2(3H)-one 1. arylaldehyde 4, and Urea 5 were treated with KF-Al2O3 in ethyl alcohol at 80 degrees C for 3-5 h, we obtained pyrrolo[2,3-d]pyrimidine derivatives in good yield. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5283 / 5285

页数：3

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