Use of Oral Anticoagulation in the Management of Atrial Fibrillation in Patients with ESRD: Con

被引：22

作者：

Keskar, Vaibhav ^{[1
]}

Sood, Manish M. ^{[2
]}

机构：

[1] Ottawa Hosp, Div Nephrol, Ottawa, ON, Canada

[2] Ottawa Hosp Res Inst, Div Nephrol, Ottawa, ON, Canada

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2016年 / 11卷 / 11期

关键词：

CHRONIC KIDNEY-DISEASE; CALCIFIC UREMIC ARTERIOLOPATHY; STAGE RENAL-DISEASE; MATRIX GLA PROTEIN; HEMODIALYSIS-PATIENTS; WARFARIN USE; RANDOMIZED-TRIALS; ISCHEMIC-STROKE; RISK-FACTORS; OUTCOMES;

D O I：

10.2215/CJN.03200316

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Among patients with atrial fibrillation, prophylaxis for stroke prevention with the use of anticoagulation is well established in the general population. A number of randomized controlled trials and evidence-based risk prediction tools clearly delineate the benefit and risks of therapy. Despite the high incidence of atrial fibrillation in the late stage CKD and ESRD populations, little high quality evidence exists in these populations. Is it appropriate then to extrapolate findings from the general population to those with CKD/ESRD? In our view, too much uncertainty exists regarding proof of efficacy with clear signals of harm. Routine anticoagulation for stroke prevention in atrial fibrillation is not recommended for the majority of CKD and ESRD patients.

引用

收藏

页码：2085 / 2092

页数：8

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