Current natural products with antihypertensive activity

被引：34
作者：
Bai Ren-Ren [1 ,2 ]
Wu Xiao-Ming [2 ,3 ]
Xu Jin-Yi [2 ,3 ]
机构：
[1] Emory Univ, Sch Med, Atlanta, GA 30322 USA
[2] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2015年 / 13卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Natural products; Antihypertensive activity; Lead compounds; Action mechanism;
D O I：
10.1016/S1875-5364(15)30072-8
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Natural products have been an important source of new drugs, which also played a dominant role in the discovery and research of new drugs for the treatment of hypertension. This review article reviews the recent progress in the research and development of natural lead compounds with antihypertensive activity, including alkaloids, diterpenes, coumarins, flavonoids, and peptides. We summarized their structures, sources, as well as the antihypertensive mechanisms. These information provides instructive reference for the following structural modifications and optimization.
引用
收藏
页码：721 / 729
页数：9
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