Vaccine-induced spike- and nucleocapsid-specific cellular responses maintain potent cross-reactivity to SARS-CoV-2 Delta and Omicron variants

被引：15

作者：

Chiuppesi, Flavia ^{[1
,2
]}

Zaia, John A. ^{[3
]}

Faircloth, Katelyn ^{[1
,2
]}

Johnson, Daisy ^{[1
,2
]}

Ly, Minh ^{[1
,2
]}

Karpinski, Veronica ^{[1
,2
]}

La Rosa, Corinna ^{[1
,2
]}

Drake, Jennifer ^{[4
]}

Marcia, Joan ^{[4
]}

Acosta, Ann Marie ^{[4
]}

Dempsey, Shannon ^{[1
,2
]}

Taplitz, Randy A. ^{[5
,6
]}

Zhou, Qiao ^{[1
,2
]}

Park, Yoonsuh ^{[1
,2
]}

Francisco, Sandra Ortega ^{[1
,2
]}

Kaltcheva, Teodora ^{[1
,2
]}

Frankel, Paul H. ^{[7
]}

Rosen, Steven ^{[1
,2
]}

Wussow, Felix ^{[1
,2
]}

Dadwal, Sanjeet ^{[5
,6
]}

Diamond, Don J. ^{[1
,2
]}

机构：

[1] Dept Hematol & HCT, 1500 E Duarte Rd, Duarte, CA 91010 USA

[2] Hematol Malignancies Res Inst, 1500 E Duarte Rd, Duarte, CA 91010 USA

[3] City Hope Natl Med Ctr, Ctr Gene Therapy, Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[4] City Hope Natl Med Ctr, Clin Trials Off, Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[5] City Hope Natl Med Ctr, Div Infect Dis, Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[6] City Hope Natl Med Ctr, Dept Med, Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[7] City Hope Natl Med Ctr, Dept Biostat, Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

来源：

ISCIENCE | 2022年 / 25卷 / 08期

关键词：

D O I：

10.1016/j.isci.2022.104745

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell-mediated immunity may contribute to providing protection against SARS-CoV-2 and its variants of concern (VOC). We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara (MVA)-based COVID-19 vaccine that stimulated potent spike (S) and nucleocapsid (N) antigen-specific humoral and cellular immunity in a phase 1 clinical trial in healthy adults. Here, we show that individuals vaccinated with COH04S1 or mRNA vaccine BNT162b2 maintain robust crossreactive cellular immunity for six or more months post-vaccination. Although neutralizing antibodies induced in COH04S1- and BNT162b2-vaccinees showed reduced activity against Delta and Omicron varLnts compared to ancestral SARS-CoV-2, S-specific T cells elicited in both COK04S1- and BNT162b2-vaccinees and N-specific T cells elicited in COH0451-vaccinees demonstrated potent and equivalent cross-reactivity against ancestral SARS-CoV-2 and the major VOC. These results suggest that vaccine-induced T cells to S and N antigens may constitute a critical second line of defense to provide long-term protection against SARS-CoV-2 VOC.

引用

页数：15

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