Inflammation and Its Relationship to Insulin Resistance, Type 2 Diabetes Mellitus, and Endothelial Dysfunction

被引：18
作者：
Barzilay, Joshua I. [1 ,2 ]
Freedland, Eric S. [3 ]
机构：
[1] Kaiser Permanente Georgia, Dept Med, Atlanta, GA USA
[2] Emory Univ, Sch Med, Div Endocrinol, Atlanta, GA USA
[3] Boston Univ, Sch Med, Dept Emergency Med, Boston Med Ctr, Boston, MA 02118 USA
来源：
METABOLIC SYNDROME AND RELATED DISORDERS | 2003年 / 1卷 / 01期
关键词：
D O I：
10.1089/154041903321648252
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In the past decade, clinical, laboratory, and epidemiological research have coalesced to give rise to a new paradigm for understanding type 2 diabetes mellitus (DM). In this review, we present data that DM has an inflammatory etiology and that inflammation plays a role in diabetic complications, especially cardiovascular disease. This new paradigm offers insight into the relationship between DM and obesity. It also suggests posible new avenues of treatment.
引用
收藏
页码：55 / 67
页数：13
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共 111 条
[51]  
Le Souëf PN, 2000, LANCET, V356, P242
[52]   Current concepts - Disseminated intravascular coagulation [J].
Levi, M ;
ten Cate, H .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) :586-592
[53]   Contribution of meat fat to dietary arachidonic acid [J].
Li, D ;
Ng, A ;
Mann, NJ ;
Sinclair, AJ .
LIPIDS, 1998, 33 (04) :437-440
[54]   Inflammation and atherosclerosis [J].
Libby, P ;
Ridker, PM ;
Maseri, A .
CIRCULATION, 2002, 105 (09) :1135-1143
[55]   Gamma globulin levels predict type 2 diabetes in the Pima Indians population [J].
Lindsay, RS ;
Krakoff, J ;
Hanson, RL ;
Bennett, PH ;
Knowler, WC .
DIABETES, 2001, 50 (07) :1598-1603
[56]   Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women [J].
Liu, SM ;
Manson, JE ;
Buring, JE ;
Stampfer, MJ ;
Willett, WC ;
Ridker, PM .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 75 (03) :492-498
[57]  
Liu SM, 2000, AM J CLIN NUTR, V71, P1455
[58]   The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes [J].
Maiorana, A ;
O'Driscoll, G ;
Cheetham, C ;
Dembo, L ;
Stanton, K ;
Goodman, C ;
Taylor, R ;
Green, D .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (03) :860-866
[59]   Circulating levels of factor VII, fibrinogen, and von Willebrand factor and features of insulin resistance in first-degree relatives of patients with NIDDM [J].
Mansfield, MW ;
Heywood, DM ;
Grant, PJ .
CIRCULATION, 1996, 94 (09) :2171-2176
[60]   Microalbuminuria and coronary heart disease in NIDDM - An incidence study [J].
Mattock, MB ;
Barnes, DJ ;
Viberti, G ;
Keen, H ;
Burt, D ;
Hughes, JM ;
Fitzgerald, AP ;
Sandhu, B ;
Jackson, PG .
DIABETES, 1998, 47 (11) :1786-1792
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