Bisphosphonates Use in Children

被引：30
作者：
Sebestyen, Judith F. [1 ]
Srivastava, Tarak [1 ]
Alon, Uri S. [1 ]
机构：
[1] Univ Missouri, Kansas City, MO 64110 USA
来源：
CLINICAL PEDIATRICS | 2012年 / 51卷 / 11期
关键词：
bisphosphonates; osteoporosis; osteogenesis imperfecta; hypercalcemia; corticosteroids; BONE-MINERAL DENSITY; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; CORTICOSTEROID-INDUCED OSTEOPOROSIS; ACUTE LYMPHOBLASTIC-LEUKEMIA; VITAMIN-D INTOXICATION; AGE-RELATED-CHANGES; OSTEOGENESIS IMPERFECTA; PAMIDRONATE TREATMENT; INTRAVENOUS PAMIDRONATE; ZOLEDRONIC ACID;
D O I：
10.1177/0009922812452118
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. In recent years, bisphosphonates have been used in children for treatment of a growing number of disorders associated primarily with generalized or localized osteoporosis, genetic and acquired metabolic bone diseases, heterotopic calcifications in soft tissues, and for hypercalcemia. In this review, the authors address the role of and experience with bisphosphonate therapy in disorders of childhood.
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收藏
页码：1011 / 1024
页数：14
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