Behavioral Correlates of Maternal Antibody Status Among Children with Autism

被引：75

作者：

Braunschweig, Daniel ^{[1
,2
,3
]}

Duncanson, Paul ^{[1
]}

Boyce, Robert ^{[1
]}

Hansen, Robin ^{[2
,3
,4
]}

Ashwood, Paul ^{[2
,3
,5
]}

Pessah, Isaac N. ^{[2
,3
,6
]}

Hertz-Picciotto, Irva ^{[2
,3
,7
]}

Van de Water, Judy ^{[1
,2
,3
]}

机构：

[1] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA

[2] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA

[3] Univ Calif Davis, NIEHS, Ctr Childrens Environm Hlth, Davis, CA 95616 USA

[4] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA

[5] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

[6] Univ Calif Davis, Dept Vet Mol Biosci, Davis, CA 95616 USA

[7] Univ Calif Davis, Dept Publ Hlth Sci, Div Epidemiol, Davis, CA 95616 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 07期

关键词：

Autism; Maternal antibodies; Autoantibodies; Fetal brain; FETAL-BRAIN; SPECTRUM DISORDER; IMMUNOGLOBULIN-G; AUTOANTIBODIES; PREGNANCY; TRANSPORT; MOTHERS; CHARGE;

D O I：

10.1007/s10803-011-1378-7

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.

引用

页码：1435 / 1445

页数：11

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