Comparative hepatitis A seroepidemiology in 10 European countries

被引：26

作者：

Kurkela, S. ^{[1
,2
]}

Pebody, R. ^{[1
]}

Kafatos, G. ^{[1
]}

Andrews, N. ^{[1
]}

Barbara, C. ^{[3
]}

Bruzzone, B. ^{[4
]}

Butur, D. ^{[5
]}

Caplinskas, S. ^{[6
]}

Davidkin, I. ^{[7
]}

Hatzakis, A. ^{[8
]}

Hellenbrand, W. ^{[9
]}

Hesketh, L. M. ^{[1
]}

Nardone, A. ^{[1
]}

Nemecek, V. ^{[10
]}

Pistol, A. ^{[11
]}

Sobotova, Z. ^{[12
]}

Vranckx, R. ^{[13
]}

Anastassopoulou, C. G. ^{[8
]}

机构：

[1] Hlth Protect Agcy, Hlth Protect Serv, London NW9 5EQ, England

[2] European Publ Hlth Microbiol Fellowship Programme, Stockholm, Sweden

[3] St Lukes Hosp, Guardamangia, Malta

[4] Univ Genoa, Dept Hlth Sci, Genoa, Italy

[5] Natl Inst Res & Dev Microbiol & Immunol Cantacuzi, Natl Reference Ctr Viral Hepatitis, Natl Ctr Expertise Med Microbiol, Bucharest, Romania

[6] Ctr Communicable Dis & AIDS, Vilnius, Lithuania

[7] Natl Inst Hlth & Welf, Helsinki, Finland

[8] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Natl Retrovirus Reference Ctr, GR-11527 Athens, Greece

[9] Robert Koch Inst, Berlin, Germany

[10] Natl Inst Publ Hlth, Prague, Czech Republic

[11] Inst Sanatate Publ Bucuresti, Bucharest, Romania

[12] Publ Hlth Author Slovak Republ, Natl Lab Poliomyelitis & Viral Hepatitis, Bratislava, Slovakia

[13] Inst Publ Hlth, Brussels, Belgium

来源：

EPIDEMIOLOGY AND INFECTION | 2012年 / 140卷 / 12期

关键词：

Epidemiology; Europe; hepatitis A; hepatitis A antibodies; incidence; serology; vaccination; VIRUS-INFECTION; YOUNG-ADULTS; OUTBREAK; SEROPREVALENCE; PREVALENCE; CHILDREN; ANTIBODY; STANDARDIZATION; POPULATION; EPIDEMIC;

D O I：

10.1017/S0950268812000015

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The WHO recommends hepatitis A virus (HAV) immunization according to level of transmission and disease burden. We aimed to identify susceptible age groups by standardized serosurveys to inform HAV vaccination policy in participating countries : Belgium, Czech Republic, England, Finland, Germany, Italy, Lithuania, Malta, Romania, and Slovakia. Each country tested national serum banks (n=1854-6748), collected during 1996-2004, for anti-HAV antibodies. Local laboratory results were standardized to common units. Forty-one per cent of those aged <30 years and 6% of those aged >= 30 years were susceptible to HAV in Romania; compared to 70-94% and 26-71%, respectively, elsewhere. Romania reported high HAV incidence in children and young adults. Other countries reported HAV disease primarily in older risk groups. The results suggest low level of HAV transmission in most of Europe. Romania, however, appeared as an area with intermediate transmission. Vaccination of risk groups in countries with high susceptibility of young and middle-aged adults needs to be continued.

引用

页码：2172 / 2181

页数：10

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