COMT Val158Met Polymorphism and Executive Functions in Obsessive-Compulsive Disorder

被引：2

作者：

Tukel, Rasit ^{[1
]}

Gurvit, Hakan ^{[2
,3
]}

Ozturk, Nalan ^{[1
]}

Ozata, Berna ^{[1
]}

Ertekin, Banu Aslantas ^{[1
]}

Ertekin, Erhan ^{[1
]}

Baran, Bengi ^{[2
,3
]}

Kalem, Sukriye Akca ^{[2
,3
]}

Buyukgok, Deniz ^{[1
]}

Direskeneli, Guher Saruhan ^{[4
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Psychiat, Istanbul, Turkey

[2] Istanbul Univ, Dept Neurol, Istanbul, Turkey

[3] Istanbul Univ, Movement Disorders Unit, Istanbul, Turkey

[4] Istanbul Univ, Dept Physiol, Istanbul, Turkey

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2013年 / 25卷 / 03期

关键词：

CATECHOL-O-METHYLTRANSFERASE; GENE POLYMORPHISM; DECISION-MAKING; MET GENOTYPE; ASSOCIATION; DOPAMINE; PERFORMANCE; SCHIZOPHRENIA; ALLELE; CORTEX;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study investigated the association between the catechol-O-methyl transferase (COMT) Val158Met polymorphism and executive functions in 101 patients with obsessive-compulsive disorder (OCD) and 100 healthy-control subjects (HS). Results showed that there was no significant difference for the genotype distributions between the OCD and HS groups. OCD-Met carrier subgroup's TMT B-A difference and lexical fluency scores were found to be significantly poorer than both HS subgroups. These findings suggest that lower activity of COMT associated with the Met allele, leading to higher levels of dopamine in the prefrontal cortex, lead to poorer executive function in OCD.

引用

页码：214 / 221

页数：8

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