Rh(III)-Catalyzed C-H Activation and Double Directing Group Strategy for the Regioselective Synthesis of Naphthyridinones

被引：178

作者：

Huckins, John R. ^{[1
]}

Bercot, Eric A. ^{[1
]}

Thiel, Oliver R. ^{[1
]}

Hwang, Tsang-Lin ^{[1
]}

Bio, Matthew M. ^{[1
]}

机构：

[1] Amgen Inc, Chem Proc Res & Dev, Thousand Oaks, CA 91320 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 39期

关键词：

PYRIDINE-N-OXIDES; ALKYNES; ANNULATION; BOND; FUNCTIONALIZATION; CLEAVAGE;

D O I：

10.1021/ja405140f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general Rh(III)-catalyzed synthesis of naphthyridinone derivatives is described. It relies on a double-activation and directing approach leveraging nicotinamide N-oxides as substrates. In general, high yields and selectivities can be achieved using low catalyst loadings and mild conditions (room temperature) in the couplings with alkynes, While alkenes require slightly more elevated temperatures.

引用

页码：14492 / 14495

页数：4

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