High-density lipoproteins delivering interleukin-15

被引：3

作者：

Ochoa, Maria C.

Melero, Ignacio

Berraondo, Pedro ^{[1
]}

机构：

[1] Univ Navarra, Div Hepatol & Gene Therapy, Ctr Appl Med Res, E-31080 Pamplona, Navarra, Spain

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 04期

关键词：

apolipoprotein AI; high-density lipoprotein; interleukin; 15; Sushi domain;

D O I：

10.4161/onci.23410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor domain involved in IL-15 trans-presentation.

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页数：3

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