Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving low-dose methotrexate treatment

被引：9

作者：

Fukushima, Masamichi ^{[1
,3
]}

Katayama, Yoichi ^{[1
]}

Yokose, Noriaki ^{[1
,3
]}

Kura, Yoshimasa ^{[2
]}

Sawada, Umihiko ^{[2
]}

Kotani, Akio ^{[3
]}

Yoshino, Atsuo ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Neurol Surg, Div Neurosurg,Itabashi Ku, Tokyo 1738610, Japan

[2] Kasukabe Municipal Hosp, Dept Haematol, Kasukabe, Saitama, Japan

[3] Kasukabe Municipal Hosp, Dept Neurosurg, Kasukabe, Saitama, Japan

来源：

BRITISH JOURNAL OF NEUROSURGERY | 2013年 / 27卷 / 06期

关键词：

methotrexate-associated lymphoproliferative disorders; primary central nervous system lymphoma; rheumatoid arthritis; spontaneous remission;

D O I：

10.3109/02688697.2013.798857

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the first case of primary central nervous system lymphoma (PCNSL) developing in a patient with rheumatoid arthritis (RA) undergoing low-dose methotrexate therapy (LD-MTX). The characteristic clinical management and course in our experience of the present case illustrate the important points about PCNSL in methotrexate-associated lymphoproliferative disorders (MTX-LPD). The number of cases of MTX-LPD in RA patients may increase in the future, since current treatment strategies for RA recommend starting MTX use in early stage RA, and recent insights have tended to show an increase with higher doses.

引用

页码：824 / 826

页数：3

共 3 条

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[2] Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research [J].

Salliot, C. ;

van der Heijde, D. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (07) :1100-1104

[3]

SWERDLLOW S., 2008, WHO classification of tumours of haematopoietic and lymphoid tissues

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