Chronic Inflammatory Diseases and the Acute Respiratory Distress Syndrome ( ARDS)

被引：13

作者：

Fernandez-Bustamante, Ana ^{[1
,2
]}

Repine, John E. ^{[2
]}

机构：

[1] Univ Colorado SOM, Dept Anesthesiol, Aurora, CO 80045 USA

[2] Univ Colorado SOM, Webb Waring Ctr, Aurora, CO 80045 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2014年 / 20卷 / 09期

关键词：

ARDS; susceptibility; modulation; chronic inflammation; ACUTE LUNG INJURY; ACTIVATED RECEPTOR-GAMMA; NECROSIS-FACTOR-ALPHA; BODY-MASS INDEX; IMPROVES INSULIN SENSITIVITY; CHRONIC ALCOHOL EXPOSURE; OBSTRUCTIVE SLEEP-APNEA; HEME OXYGENASE-1; METABOLIC SYNDROME; CIGARETTE-SMOKING;

D O I：

10.2174/13816128113199990561

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Acute Respiratory Distress Syndrome (ARDS) is a highly fatal pro-inflammatoryoxidative respiratory disease. Relatively recently, the modulating effects of chronic inflammatory processes on ARDS susceptibility have been recognized in a number of clinical studies. Herein, we briefly review some of the chronic conditions that have been reported to increase (cigarette smoking and alcohol abuse) or decrease (diabetes and obesity) susceptibility to ARDS. We also propose some potential pathways that may hold clues regarding the pathogenesis and/or therapy for ARDS.

引用

页码：1400 / 1408

页数：9

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