Multicomponent Reactions as a Powerful Tool for Generic Drug Synthesis

被引：110

作者：

Kalinski, Cedric ^{[1
]}

Lemoine, Hugues ^{[1
]}

Schmidt, Juergen ^{[1
]}

Burdack, Christoph ^{[1
]}

Kolb, Juergen ^{[1
]}

Umkehrer, Michael ^{[1
]}

Ross, Guenther ^{[1
]}

机构：

[1] Priaxon AG, D-81739 Munich, Germany

来源：

SYNTHESIS-STUTTGART | 2008年 / 24期

关键词：

multicomponent reactions; drugs; cleavage; clopidogrel; bicalutamide;

D O I：

10.1055/s-0028-1083239

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multicomponent reactions (MCRs) are not only a powerful tool for drug discovery, they also represent an excellent methodology for synthesis rationalization. Here we wish to illustrate the potential of MCRs in the production of generic drugs by synthesizing, in racemic form, the antiplatelet agent clopidogrel and the nonsteroidal antiandrogen bicalutamide, using Ugi, Petasis and Passerini reactions.

引用

页码：4007 / 4011

页数：5

共 36 条

[1]

[Anonymous], 2007, US Patent, Patent No. 7199257

[2] HIGHLY DIASTEREOSELECTIVE REACTION OF A CHIRAL, NON-RACEMIC AMIDE ENOLATE WITH (S)-GLYCIDYL TOSYLATE - SYNTHESIS OF THE ORALLY-ACTIVE HIV-1 PROTEASE INHIBITOR L-735,524 [J].