Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

被引：106

作者：

Gujral, Palak ^{[1
]}

Mahajan, Vishakha ^{[1
,2
]}

Lissaman, Abbey C. ^{[1
,2
]}

Ponnampalam, Anna P. ^{[1
,2
,3
]}

机构：

[1] Univ Auckland, Liggins Inst, Auckland, New Zealand

[2] Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland, New Zealand

[3] Univ Auckland, Fac Med & Hlth Sci, Dept Physiol, Private Bag 92019, Auckland 1142, New Zealand

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2020年 / 18卷 / 01期

关键词：

Histone acetylation; Histone deacetylation; Endometrium; Menstrual cycle; MESENCHYMAL STEM-CELLS; EPIGENETIC REGULATION; DOWN-REGULATION; MOLECULAR-MECHANISMS; GENOME-WIDE; EXPRESSION; PATHOGENESIS; INHIBITORS; CHROMATIN; HDAC;

D O I：

10.1186/s12958-020-00637-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The human endometrium goes through cycles of regeneration, proliferation, differentiation, and degradation each month; each phase requiring strict epigenetic regulation for the proper functioning of the endometrium. Aberrant histone acetylation and alterations in levels of two acetylation modulators - histone acetylases (HATs) and histone deacetylases (HDACs) - have been associated with endometrial pathologies such as endometrial cancer, implantation failures, and endometriosis. Thus, histone acetylation is likely to have an essential role in the regulation of endometrial remodelling throughout the menstrual cycle.

引用

页数：11

共 108 条

[31] Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together? [J].