Biomarkers in autism

被引：152

作者：

Goldani, Andre A. S. ^{[1
]}

Downs, Susan R. ^{[2
]}

Widjaja, Felicia ^{[2
]}

Lawton, Brittany ^{[2
]}

Hendren, Robert L. ^{[2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil

[2] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

来源：

FRONTIERS IN PSYCHIATRY | 2014年 / 5卷

关键词：

biomarker; autism spectrum disorders; epigenetics; treatment targets; neuroimaging; genetics; BLOOD-BRAIN-BARRIER; FATTY-ACID COMPOSITIONS; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; SPECTRUM DISORDERS; VITAMIN-D; DEVELOPMENTAL REGRESSION; INCREASED FREQUENCY; LIPID-PEROXIDATION; IMMUNE-RESPONSE;

D O I：

10.3389/fpsyt.2014.00100

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Autism spectrum disorders (ASDs) are complex, heterogeneous disorders caused by an interaction between genetic vulnerability and environmental factors. In an effort to better target the underlying roots of ASD for diagnosis and treatment, efforts to identify reliable biomarkers in genetics, neuroimaging, gene expression, and measures of the bodys metabolism are growing. For this article, we review the published studies of potential biomarkers in autism and conclude that while there is increasing promise of finding biomarkers that can help us target treatment, there are none with enough evidence to support routine clinical use unless medical illness is suspected. Promising biomarkers include those for mitochondrial function, oxidative stress, and immune function. Genetic clusters are also suggesting the potential for useful biomarkers.

引用

页数：13

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