TP53 or Not TP53: That Is the Question

被引：0

作者：

Green, Steven D. ^{[1
]}

Zeidner, Joshua F. ^{[2
,3
]}

机构：

[1] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Med, Div Hematol, 170 Manning Dr,Houpt Bldg,CB7305, Chapel Hill, NC 27599 USA

来源：

CLINICAL CANCER RESEARCH | 2022年 / 28卷 / 24期

关键词：

ACUTE MYELOID-LEUKEMIA; CLASSIFICATION; VALIDATION;

D O I：

10.1158/1078-0432.CCR-22-2664

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Azacitidine and venetoclax are a standard first-line regimen for patients with newly diagnosed unfit acute myeloid leukemia (AML). In a pooled subset analysis, TP53-mutated AML with poor-risk cytogenetics does not appear to benefit from the addition of venetoclax to azacitidine. This has clinical implications as these patients should be preferentially treated with alternative regimens.

引用

页码：5235 / 5237

页数：3

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