Miltefosine represses HIV-1 replication in human dendritic cell/T-cell cocultures partially by inducing secretion of type-I interferon

被引：12
作者：
Garg, Ravendra [1 ]
Tremblay, Michel J. [1 ,2 ]
机构：
[1] CHUL, CHU Quebec, Ctr Rech Infectiol, Quebec City, PQ G1V 4G2, Canada
[2] Univ Laval, Dept Microbiol Infectiol & Immunol, Dept Med, Quebec City, PQ, Canada
来源：
VIROLOGY | 2012年 / 432卷 / 02期
基金：
加拿大健康研究院;
关键词：
HIV-1; AIDS; Miltefosine; T cells and dendritic cells; HEXADECYLPHOSPHOCHOLINE MILTEFOSINE; VISCERAL LEISHMANIASIS; ORAL MILTEFOSINE; INFECTION; MECHANISMS; STRAINS; PATHOGENESIS; RESTRICTION; LYMPHOCYTES; MACROPHAGES;
D O I：
10.1016/j.virol.2012.05.032
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Miltefosine (Milt) was originally synthesized as an antineoplastic agent but this phospholipid drug is now clinically used as an antiprotozoal compound. We demonstrate here that Milt reduces replication of HIV-1 in cocultures of human dendritic cells (DCs) and CDA(+) T cells. This phenomenon is due to a rapid secretion of soluble factors by DCs. We present evidence that the Milt-mediated repression in virus production is associated with induction of type-I interferon (IFN) in DCs. The Milt-dependent diminution in HIV-1 production was not totally abrogated by B18R, a vaccinia virus-encoded neutralizing type-I IFN receptor, which suggests the involvement of another yet to be identified soluble factor. Altogether, these results suggest that a therapy with Milt when used to control protozoan infections in individuals also carrying HIV-1 might also help to limit viral load. Additional studies are warranted to estimate the exact therapeutic potential of Milt as an anti-HIV-1 agent. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：271 / 276
页数：6
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