The preparation and anticancer activity of some phosphorus heterocycles

被引：34

作者：

Hudson, Harry R. ^{[2
]}

Keglevich, Gyoergy ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

[2] London Metropolitan Univ, Dept Hlth & Human Sci, London, England

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 09期

基金：

匈牙利科学研究基金会;

关键词：

anticancer; dihydrophosphinine; NCI; organophosphorus; phosphanorbornene; phosphole oxide; phosphorus heterocycle; tetrahydrophosphinine;

D O I：

10.1080/10426500801938592

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Methods for the preparation of some phosphorus heterocycles are reviewed, together with a preliminary report of their activity in vitro against the NCI 60-cell line panel of human tumour cells. The most active compound, a dimer of 3-methyl-1-(2,4,6-triisopropylphenyl)phosphole oxide, showed GI(50) values in the micromolar region against leukaemia cell lines RPMI-8226 and SR, non-small cell lung cancer (NCI-H460), colon cancer (COLO 205), and melanoma (SK-Mel-5 and UACC-62).

引用

页码：2256 / 2261

页数：6

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