CSF-1/CSF-1R targeting agents in clinical development for cancer therapy

被引：110
|
作者：
Ries, Carola H. [1 ]
Hoves, Sabine [1 ]
Cannarile, Michael A. [1 ]
Ruettinger, Dominik [1 ]
机构：
[1] Roche Innovat Ctr Penzberg, Roche Pharmaceut Res & Early Dev, Nonnenwald 2, D-82377 Penzberg, Germany
来源：
CURRENT OPINION IN PHARMACOLOGY | 2015年 / 23卷
关键词：
TUMOR-ASSOCIATED MACROPHAGES; INFILTRATING MYELOID CELLS; KINASE INHIBITOR; GENETIC PROGRAMS; C-FMS; IMPROVES; POLARIZATION; EFFICACY; ANTIBODY; REVEALS;
D O I：
10.1016/j.coph.2015.05.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Macrophage infiltration has been identified as an independent poor prognostic factor for several cancer entities. In mouse tumor models macrophages orchestrate various tumor-promoting processes. This observation sparked an interest to therapeutically target these plastic innate immune cells. To date, blockade of colony stimulating factor-1 or its receptor represents the only truly selective approach to manipulate macrophages in cancer patients. Here, we discuss the currently available information on efficacy and safety of various CSF-1/CSF-1R inhibitors in cancer patients and highlight potential combination partners emerging from preclinical studies while considering the differences between mouse and human macrophage biology.
引用
收藏
页码：45 / 51
页数：7
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