DETECTING SEX-BIASED GENE FLOW IN AFRICAN-AMERICANS THROUGH THE ANALYSIS OF INTRA- AND INTER-POPULATION VARIATION AT MITOCHONDRIAL DNA AND Y- CHROMOSOME MICROSATELLITES

被引：4

作者：

Battaggia, C. ^{[1
]}

Anagnostou, P. ^{[1
,3
]}

Bosch, I ^{[4
]}

Brisighelli, F. ^{[4
]}

Destro-Bisol, G. ^{[1
,3
]}

Capocasa, M. ^{[2
,3
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Biol Ambientale, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Biol & Biotecnol Charles Darwin, I-00185 Rome, Italy

[3] Ist Italiano Antropol, Rome, Italy

[4] Univ Cattolica, Ist Med Legale, Rome, Italy

来源：

BALKAN JOURNAL OF MEDICAL GENETICS | 2012年 / 15卷 / 02期

关键词：

Admixture; African-Americans; Mitochondrial DNA (mtDNA); Sex-biased gene flow; Y-chromosome; BANTU EXPANSION; SLAVE-TRADE; ADMIXTURE; PROPORTIONS; HAPLOTYPES; MIGRATION; ANCESTRY; ORIGINS; HISTORY; SNPS;

D O I：

10.2478/bjmg-2013-0001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This study reports on variations at the mitochondrial DNA (mtDNA) hypervariable region 1 (HVR-1) and at seven Y-chromosome microsatellites in an African-American population sample from Chicago, IL, USA. Our results support the hypothesis that the population studied had undergone a European male-biased gene flow. We show that comparisons of intra-and inter-population diversity parameters between African-Americans, Europeans and Africans may help detect sex-biased gene flow, providing a complement to quantitative methods to estimate genetic admixture.

引用

页码：7 / 13

页数：7