Is There a Place for Cerebral Preconditioning in the Clinic?

被引：26

作者：

Keep, Richard F. ^{[1
,2
]}

Wang, Michael M. ^{[1
,3
]}

Xiang, Jianming ^{[1
]}

Hua, Ya ^{[1
]}

Xi, Guohua ^{[1
]}

机构：

[1] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2010年 / 1卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Translational research; Preconditioning; Ischemic tolerance; Cerebral ischemia; TRANSIENT ISCHEMIC ATTACK; HEALTH-CARE PROFESSIONALS; ARTERY-BYPASS SURGERY; SHORT-TERM PROGNOSIS; BRAIN EDEMA; HYPERBARIC-OXYGEN; INDUCED TOLERANCE; FOCAL ISCHEMIA; UP-REGULATION; DOUBLE-BLIND;

D O I：

10.1007/s12975-009-0007-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Preconditioning (PC) describes a phenomenon whereby a sub-injury-inducing stress can protect against a later injurious stress. Great strides have been made in identifying the mechanisms of PC-induced protection in animal models of brain injury. While these may help elucidate potential therapeutic targets, there are questions over the clinical utility of cerebral PC, primarily because of questions over the need to give the PC stimulus prior to the injury, narrow therapeutic windows, and safety. The object of this review is to address the question of whether there may indeed be a clinical use for cerebral PC and to discuss the deficiencies in our knowledge of PC that may hamper such clinical translation.

引用

页码：4 / 18

页数：15

共 147 条

[1] Induced hippocampal neuron protection in an optimized gerbil ischemia model: Insult thresholds for tolerance induction and altered gene expression defined by ischemic depolarization [J].

Abe, H ;

Nowak, TS .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (01) :84-97

[2] Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: A prospective randomized double-blind trial [J].

Alex, J ;

Laden, G ;

Cale, ARJ ;

Bennett, S ;

Flowers, K ;

Madden, L ;

Gardiner, E ;

McCollum, PT ;

Griffin, SC .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2005, 130 (06) :1623-1630

[3] Neuroprotection and P4502C11 upregulation after experimental transient ischemic attack [J].

Alkayed, NJ ;

Goyagi, T ;

Joh, HD ;

Klaus, J ;

Harder, DR ;

Traystman, RJ ;

Hurn, PD .

STROKE, 2002, 33 (06) :1677-1684

[4]

Amarenco P, 2006, NEW ENGL J MED, V355, P549

[5] The protective effects of preconditioning on cerebral endothelial cells in vitro [J].

Andjelkovic, AV ;

Stamatovic, SM ;

Keep, RF .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (11) :1348-1355

[6] Ischemic preconditioning and brain tolerance - Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression [J].

Barone, FC ;

White, RF ;

Spera, PA ;

Ellison, J ;

Currie, RW ;

Wang, XK ;

Feuerstein, GZ .

STROKE, 1998, 29 (09) :1937-1950

[7] Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation -: Role of intracellular Ca2+ and mitogen-activated protein kinase signaling [J].

Bickler, PE ;

Zhan, XH ;

Fahlman, CS .

ANESTHESIOLOGY, 2005, 103 (03) :532-539

[8] In vivo preconditioning with normobaric hyperoxia induces ischemic tolerance partly by triggering tumor necrosis factor-α converting enzyme/tumor necrosis factor-α/nuclear factor-κB [J].

Bigdeli, M. R. ;

Khoshbaten, A. .

NEUROSCIENCE, 2008, 153 (03) :671-678

[9] Isoflurane pretreatment ameliorates postischemic neurologic dysfunction and preserves hippocampal Ca2+/calmodulin-dependent protein kinase in a canine cardiac arrest model [J].

Blanck, TJJ ;

Haile, M ;

Xu, F ;

Zhang, J ;

Heerdt, P ;

Veselis, RA ;

Beekman, J ;

Kang, R ;

Adamo, A ;

Hemmings, H .

ANESTHESIOLOGY, 2000, 93 (05) :1285-1293

[10] Kidney ischemic preconditioning [J].

Bonventre, JV .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2002, 11 (01) :43-48

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