A high yielding route to substituted piperidines via the aza-Diels-Alder reaction

被引：19

作者：

Bailey, PD

Smith, PD

Pederson, F

Clegg, W

Rosair, GM

Teat, SJ

机构：

[1] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[2] CLRC, Daresbury Lab, Warrington WA4 4AD, Cheshire, England

[3] Newcastle Univ, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

关键词：

alkaloids; Diels-Alder reaction; piperidines;

D O I：

10.1016/S0040-4039(01)02148-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The imine Ph2CHN-CHCO2Et, generated from benzhydrylamine and ethyl glyoxylate, is an excellent dienophile in aza-Diels-Alder reactions, giving diastereomerically pure cycloadducts in high yield. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1067 / 1070

页数：4

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