The Roles of Immune Cells in the Pathogenesis of Fibrosis

被引：90

作者：

Huang, Enyu ^{[1
,2
]}

Peng, Na ^{[3
]}

Xiao, Fan ^{[1
,2
]}

Hu, Dajun ^{[3
]}

Wang, Xiaohui ^{[1
,2
]}

Lu, Liwei ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Pathol, Hong Kong, Peoples R China

[2] Univ Hong Kong, Shenzhen Inst Res & Innovat, Hong Kong, Peoples R China

[3] Three Gorges Univ, Dept Rheumatol & Immunol, Peoples Hosp 2, Yichang 443000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 15期

基金：

中国国家自然科学基金;

关键词：

fibrosis; innate immune cells; adaptive immune cells; myofibroblast; molecular mechanism; INNATE LYMPHOID-CELLS; REGULATORY T-CELLS; HEPATIC STELLATE CELLS; NATURAL-KILLER-CELLS; INDUCED PULMONARY-FIBROSIS; LIVER FIBROSIS; TGF-BETA; LUNG FIBROSIS; SYSTEMIC-SCLEROSIS; KUPFFER CELLS;

D O I：

10.3390/ijms21155203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.

引用

页码：1 / 27

页数：27

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