New Insights into the Biology and Pathobiology of Beta2-Glycoprotein I

被引：18

作者：

Giannakopoulos, Bill ^{[1
,2
,3
]}

Mirarabshahi, Peyman ^{[1
]}

Krilis, Steven A. ^{[1
]}

机构：

[1] Univ New S Wales, St George Publ Hosp, Dept Immunol Allergy & Infect Dis, Sydney, NSW, Australia

[2] Univ New S Wales, St George Publ Hosp, Dept Med, Sydney, NSW, Australia

[3] Univ New S Wales, St George Publ Hosp, Dept Rheumatol, Sydney, NSW, Australia

来源：

CURRENT RHEUMATOLOGY REPORTS | 2011年 / 13卷 / 01期

基金：

英国医学研究理事会;

关键词：

Beta2-glycoprotein I; Physiology; Autoimmunity; Antiphospholipid syndrome;

D O I：

10.1007/s11926-010-0151-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

beta 2-glycoprotein I (beta 2GPI) is the major autoantigen in the antiphospholipid syndrome. The central importance of understanding beta 2GPI physiology from the perspective of the rheumatologist is that it forms the foundation for understanding the pathophysiology underlying autoantibody generation, and the diverse mechanisms by which anti-beta 2GPI antibodies in complex with beta 2GPI may predispose an individual to the antiphospholipid syndrome clinical phenotype. This review examines some of the latest novel findings in this area.

引用

页码：90 / 95

页数：6

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