Suppressive Effect on Food Intake of a Potato Extract (Potein®) Involving Cholecystokinin Release in Rats

被引：21

作者：

Chen, Wenya ^{[2
]}

Hira, Tohru ^{[1
]}

Nakajima, Shingo ^{[2
]}

Tomozawa, Hiroshi ^{[3
]}

Tsubata, Masahito ^{[3
]}

Yamaguchi, Kazuya ^{[3
]}

Hara, Hiroshi ^{[1
]}

机构：

[1] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608589, Japan

[2] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Kita Ku, Sapporo, Hokkaido 0608589, Japan

[3] Toyo Shinyaku Co Ltd, Hakata Ku, Fukuoka 8120011, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 06期

关键词：

potato extract; cholecystokinin; appetite; rat; devazepide; ENTEROENDOCRINE CELLS; PROTEASE INHIBITORS; GENE-TRANSCRIPTION; METABOLIC SYNDROME; SECRETION; CCK; PEPTONE; APPETITE;

D O I：

10.1271/bbb.110936

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently reported that oral gavage of a potato extract (Potein (R)) suppressed the food intake in rats. The satiating effect of the potato extract was compared in the present study to other protein sources, and the involvement of endogenous cholecystokinin (CCK) secretion was examined. Food consumption was measured in 18-h fasted rats after oral gavage of the potato extract or other protein sources. The CCK-releasing activity of the potato extract was then examined in anesthetized rats with a portal cannula. Oral gavage of the potato extract reduced the food intake in the rats, the effect being greater than with casein and a soybean beta-conglycinin hydrolysate. The suppressive effect on appetite of the potato extract was attenuated by treating with a CCK-receptor antagonist (devazepide). The portal CCK concentration was increased after a duodenal administration of the potato extract to anesthetized rats. These results indicate that the potato extract suppressed the food intake in rats through CCK secretion.

引用

页码：1104 / 1109

页数：6

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