In Situ Detection of Liver Cancer Biomarkers with Atomic Force Microscopy at a Single-molecule Level

被引：1

作者：

Tang, Bochong ^{[1
]}

Li, Min ^{[1
]}

Zhang, Xiao ^{[1
,2
]}

Wang, Jiaojiao ^{[1
,3
]}

Xie, Peng ^{[1
]}

Zhao, Yuliang ^{[1
]}

Wei, Zhongqing ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

[2] Shandong Univ Sci & Technol, Coll Sci, Qingdao 266590, Peoples R China

[3] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China

来源：

CHEMISTRY LETTERS | 2013年 / 42卷 / 10期

关键词：

GRAPHENE OXIDE; NANOARRAYS; MARKERS; CELLS;

D O I：

10.1246/cl.130440

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

alpha-Fetoprotein (AFP), a surveillance biomarker of liver cancer, was directly detected via immunoassay at a single-molecule level using in situ atomic force microscopy (AFM). AFM size measurements confirmed the successful capture of single APP molecules by monoclonal antibody molecules on a one-to-one basis.

引用

页码：1154 / 1156

页数：3

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