In Situ Detection of Liver Cancer Biomarkers with Atomic Force Microscopy at a Single-molecule Level

被引：1
|
作者：
Tang, Bochong [1 ]
Li, Min [1 ]
Zhang, Xiao [1 ,2 ]
Wang, Jiaojiao [1 ,3 ]
Xie, Peng [1 ]
Zhao, Yuliang [1 ]
Wei, Zhongqing [1 ]
机构：
[1] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
[2] Shandong Univ Sci & Technol, Coll Sci, Qingdao 266590, Peoples R China
[3] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
来源：
CHEMISTRY LETTERS | 2013年 / 42卷 / 10期
关键词：
GRAPHENE OXIDE; NANOARRAYS; MARKERS; CELLS;
D O I：
10.1246/cl.130440
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
alpha-Fetoprotein (AFP), a surveillance biomarker of liver cancer, was directly detected via immunoassay at a single-molecule level using in situ atomic force microscopy (AFM). AFM size measurements confirmed the successful capture of single APP molecules by monoclonal antibody molecules on a one-to-one basis.
引用
收藏
页码：1154 / 1156
页数：3
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