Dectin-1 plays a redundant role in the immunomodulatory activities of β-glucan-rich ligands in vivo

被引：77

作者：

Marakalala, Mohlopheni J. ^{[1
]}

Williams, David L. ^{[2
]}

Hoving, Jennifer C. ^{[1
]}

Engstad, Rolf ^{[3
]}

Netea, Mihai G. ^{[4
]}

Brown, Gordon D. ^{[1
]}

机构：

[1] Univ Cape Town, Inst Infect Dis & Mol Med, Div Immunol, ZA-7700 Rondebosch, South Africa

[2] E Tennessee State Univ, James H Quillen Coll Med, Dept Surg, Johnson City, TN 37614 USA

[3] Biotec BetaGlucans AS, N-9294 Tromso, Norway

[4] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6525 ED Nijmegen, Netherlands

来源：

MICROBES AND INFECTION | 2013年 / 15卷 / 6-7期

基金：

新加坡国家研究基金会; 英国惠康基金; 英国医学研究理事会;

关键词：

Innate immunity; Immunomodulation; Dectin-1; Beta-glucan; MODS; Staphylococcus aureus; INCREASED RESISTANCE; IMMUNE-RESPONSES; INFLAMMATION; PARTICULATE; INFECTION; RECEPTOR; DEFENSE; INNATE;

D O I：

10.1016/j.micinf.2013.03.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified beta-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these beta-glucan rich compounds had marked effects in vivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models. (c) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：511 / 515

页数：5

共 22 条

[1] Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching [J].

Adams, Elizabeth L. ;

Rice, Peter J. ;

Graves, Bridget ;

Ensley, Harry E. ;

Yu, Hai ;

Brown, Gordon D. ;

Gordon, Siamon ;

Monteiro, Mario A. ;

Papp-Szabo, Erzsebet ;

Lowman, Douglas W. ;

Power, Trevor D. ;

Wempe, Michael F. ;

Williams, David L. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 325 (01) :115-123

[2] Dectin-1 is a major β-glucan receptor on macrophages [J].

Brown, GD ;

Taylor, PR ;

Reid, DM ;

Willment, JA ;

Williams, DL ;

Martinez-Pomares, L ;

Wong, SYC ;

Gordon, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) :407-412

[3] Dectin-1 mediates the biological effects of β-glucans [J].

Brown, GD ;

Herre, J ;

Williams, DL ;

Willment, JA ;

Marshall, ASJ ;

Gordon, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1119-1124

[4] Fungal β-glucans and mammalian immunity [J].

Brown, GD ;

Gordon, S .

IMMUNITY, 2003, 19 (03) :311-315

[5] PROTECTIVE EFFECT OF GLUCAN AGAINST SYSTEMIC STAPHYLOCOCCUS-AUREUS SEPTICEMIA IN NORMAL AND LEUKEMIC MICE [J].

DILUZIO, NR ;

WILLIAMS, DL .

INFECTION AND IMMUNITY, 1978, 20 (03) :804-810

[6] The role of Dectin-1 in the host defence against fungal infections [J].

Drummond, Rebecca A. ;

Brown, Gordon D. .

CURRENT OPINION IN MICROBIOLOGY, 2011, 14 (04) :392-399

[7] Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse' [J].

Goodridge, Helen S. ;

Reyes, Christopher N. ;

Becker, Courtney A. ;

Katsumoto, Tamiko R. ;

Ma, Jun ;

Wolf, Andrea J. ;

Bose, Nandita ;

Chan, Anissa S. H. ;

Magee, Andrew S. ;

Danielson, Michael E. ;

Weiss, Arthur ;

Vasilakos, John P. ;

Underhill, David M. .

NATURE, 2011, 472 (7344) :471-U541

[8] Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells [J].

Goodridge, Helen S. ;

Shimada, Takahiro ;

Wolf, Andrea J. ;

Hsu, Yen-Michael S. ;

Becker, Courtney A. ;

Lin, Xin ;

Underhill, David M. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :1146-1154

[9] Relative Contributions of Dectin-1 and Complement to Immune Responses to Particulate β-Glucans [J].

Huang, Haibin ;

Ostroff, Gary R. ;

Lee, Chrono K. ;

Agarwal, Sarika ;

Ram, Sanjay ;

Rice, Peter A. ;

Specht, Charles A. ;

Levitz, Stuart M. .

JOURNAL OF IMMUNOLOGY, 2012, 189 (01) :312-317

[10] Gradual development of organ damage in the murine zymosan-induced multiple organ dysfunction syndrome [J].

Jansen, MJJM ;

Hendriks, T ;

Verhofstad, AAJ ;

Lange, W ;

Geeraedts, LMG ;

Goris, RJA .

SHOCK, 1997, 8 (04) :261-267

← 1 2 3 →