Potential Inflammatory Biomarker in Patients with Attention Deficit Hyperactivity Disorder

被引：5
作者：
Park, Ji Hyun [1 ]
机构：
[1] Duksung Womens Univ, Coll Pharm, Seoul 01369, South Korea
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 21期
基金：
新加坡国家研究基金会;
关键词：
kynurenine pathway; inflammatory biomarkers; inflammation; ADHD; neurobiology; kynurenine; DEFICIT/HYPERACTIVITY DISORDER; KYNURENINE PATHWAY; INDOLEAMINE 2,3-DIOXYGENASE; TRYPTOPHAN-METABOLISM; QUINOLINIC ACID; IFN-GAMMA; RAT-BRAIN; DEPENDENT ASSOCIATION; SERUM-LEVELS; CHILDREN;
D O I：
10.3390/ijms232113054
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder that can diminish the quality of life of both children and adults in academic, occupational, and social contexts. The kynurenine pathway (KP) contains a set of enzymatic reactions involved in tryptophan (TRP) degradation. It is known to be associated with the risk of developing ADHD. This review will address the KP and underlying mechanism of inflammation in ADHD. Potential inflammatory biomarkers reported in the most recent studies are summarized. Although a strong neuroimmunological basis has been established due to the advances of recent neurobiological research, the pathophysiology of ADHD remains unclear.
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页数：15
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