Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

被引：43

作者：

Incorvaia, Cristoforo ^{[1
]}

Al-Ahmad, Mona ^{[2
,3
]}

Ansotegui, Ignacio J. ^{[4
]}

Arasi, Stefania ^{[5
]}

Bachert, Claus ^{[6
,7
,8
]}

Bos, Catherine ^{[9
]}

Bousquet, Jean ^{[10
]}

Bozek, Andrzej ^{[11
]}

Caimmi, Davide ^{[12
]}

Calderon, Moises A. ^{[13
]}

Casale, Thomas ^{[14
]}

Custovic, Adnan ^{[15
,16
]}

De Blay, Frederic ^{[17
]}

Demoly, Pascal ^{[12
,18
]}

Devillier, Philippe ^{[19
]}

Didier, Alain ^{[20
]}

Fiocchi, Alessandro ^{[5
]}

Fox, Adam T. ^{[21
]}

Gevaert, Philippe ^{[6
]}

Gomez, Maximiliano ^{[22
]}

Heffler, Enrico ^{[23
,24
]}

Ilina, Natalia ^{[25
]}

Irani, Carla ^{[26
]}

Jutel, Marek ^{[27
]}

Karagiannis, Efstrathios ^{[9
]}

Klimek, Ludger ^{[28
]}

Kuna, Piotr ^{[29
]}

O'Hehir, Robin ^{[30
,31
]}

Kurbacheva, Oxana ^{[32
]}

Matricardi, Paolo M. ^{[33
]}

Morais-Almeida, Mario ^{[34
,35
]}

Mosges, Ralph ^{[36
,37
]}

Novak, Natalija ^{[38
]}

Okamoto, Yoshitaka ^{[39
]}

Panzner, Petr ^{[40
]}

Papadopoulos, Nikolaos G. ^{[41
,42
]}

Park, Hae-Sim ^{[43
]}

Passalacqua, Giovanni ^{[44
]}

Pawankar, Ruby ^{[45
]}

Pfaar, Oliver ^{[46
]}

Schmid-Grendelmeier, Peter ^{[47
]}

Scurati, Silvia ^{[9
]}

Tortajada-Girbes, Miguel ^{[48
,49
,50
]}

Vidal, Carmen ^{[51
]}

Virchow, J. Christian ^{[52
]}

Wahn, Ulrich ^{[33
]}

Worm, Margitta ^{[33
]}

Zieglmayer, Petra ^{[53
]}

Canonica, Giorgio W. ^{[23
,35
]}

机构：

[1] ASST Pini CTO, Cardiac Pulm Rehabil, Milan, Italy

[2] Kuwait Univ, Microbiol Dept, Fac Med, Kuwait, Kuwait

[3] Al Rashed Allergy Ctr, Dept Allergy, Drug Allergy Unit, Kuwait, Kuwait

[4] Hosp Quironsalud Bizkaia, Bilbao, Spain

[5] Bambino Gesu Childrens Hosp IRCCS, Dept Allergy, Rome, Italy

[6] Ghent Univ Hosp, ENT Dept, Upper Airways Res Lab, Ghent, Belgium

[7] Karolinska Inst, Stockholm, Sweden

[8] Karolinska Univ Hosp, Dept ENT Dis, Stockholm, Sweden

[9] Stallergenes Greer Med Affairs Dept, Antony, France

[10] Univ Hosp Montpellier, MACVIA France, Montpellier, France

[11] Med Univ Silesia, Clin Dept Internal Dis Dermatol & Allergol, Katowice, Poland

[12] Montpellier Univ, Arnaud Villeneuve Hosp, Dept Pulmonol & Addictol, Montpellier, France

[13] Imperial Coll London, Royal Brompton Hosp NHS, Natl Heart & Lung Inst, London, England

[14] Univ S Florida, Div Allergy Immunol, Tampa, FL 33620 USA

[15] Univ Manchester, Inst Inflammat & Repair, Ctr Resp Med & Allergy, Manchester, Lancs, England

[16] Univ Hosp South Manchester, Manchester, Lancs, England

[17] Strasbourg Univ Hosp, Allergy Div, Chest Dis Dept, Strasbourg, France

[18] Sorbonne Univ, INSERM, IPLESP, EPAR Team,UMR S 1136, Paris, France

[19] Univ Paris Saclay, Lab Rech Pharmacol Resp, Pole Malad Voies Resp, Hop Foch, Suresnes, France

[20] Paul Sabatier Univ, Univ Hosp Toulouse, Larrey Hosp, Resp Dis Dept, Toulouse, France

[21] Guys St Thomas Hosp NHS Fdn Trust, Dept Paediat Allergy, London, England

[22] Hosp San Bernardo Salta, Allergy & Asthma Unit, Salta, Argentina

[23] Humanitas Clin & Res Ctr IRCCS, Personalized Med Asthma & Allergy, Rozzano, Italy

[24] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, Italy

[25] Fed Inst Immunol Russia, Moscow, Russia

[26] St Joseph Univ, Hotel Dieu France Hosp, Dept Internal Med & Clin Immunol, Fac Med, Beirut, Lebanon

[27] Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland

[28] Ctr Rhinol & Allergol, Wiesbaden, Germany

[29] Med Univ Lodz, Barlicki Univ Hosp, Div Internal Med Asthma & Allergy, Lodz, Poland

[30] Alfred Hosp, Melbourne, Vic, Australia

[31] Monash Univ, Melbourne, Vic, Australia

[32] Fed Med Biol Agcy Russia, Inst Immunol Fed Med, Natl Res Ctr, Moscow, Russia

[33] Charite Univ Med Berlin, Dept Pediat Pulmonol Immunol & Intens Care Med, Berlin, Germany

[34] CUF Descobertas Hosp, Immunoallergy Dept, Lisbon, Portugal

[35] CUF Infante Santo Hosp, Lisbon, Portugal

[36] Univ Cologne, Inst Med Stat & Computat Biol, Fac Med, Cologne, Germany

[37] CRI Clin Res Int Ltd, Cologne, Germany

[38] Univ Hosp Bonn, Dept Dermatol & Allergy, Bonn, Germany

[39] Chiba Univ Hosp, Dept Otorhinolaryngol, Chiba, Japan

[40] Charles Univ Prague, Fac Med Pilsen, Dept Immunol & Allergol, Plzen, Czech Republic

[41] Univ Manchester, Royal Manchester Childrens Hosp, Div Infect Immun & Resp Med, Manchester, Lancs, England

[42] Univ Athens, Athens Gen Childrens Hosp P&A Kyriakou, Allergy Dept, Pediat Clin 2, Athens, Greece

[43] Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea

[44] Univ Genoa, Allergy & Resp Dis, Osped Policlin San Martino, Genoa, Italy

[45] Nippon Med Sch, Dept Pediat, Tokyo, Japan

[46] Philipps Univ Marburg, Sect Rhinol & Allergy, Dept Otorhinolaryngol Head & Neck Surg, Univ Hosp Marburg, Marburg, Germany

[47] Univ Zurich Hosp, Dept Dermatol, Zurich, Switzerland

[48] Dr Peset Univ Hosp, Dept Pediat, Pediat Pulmonol & Allergy Unit, Valencia, Spain

[49] Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia, Spain

[50] IVI Fdn, Valencia, Spain

来源：

ALLERGY | 2021年 / 76卷 / 04期

关键词：

allergen immunotherapy; molecular diagnosis; omics; personalized medicine; treatable traits; SUBLINGUAL IMMUNOTHERAPY; MOLECULAR DIAGNOSIS; PRECISION MEDICINE; TREATABLE TRAITS; CONTROLLED-TRIAL; ASTHMA; EFFICACY; PHARMACOTHERAPY; PRESCRIPTION; PERFORMANCE;

D O I：

10.1111/all.14575

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to detect specific IgE to single-allergen molecules and to distinguish the causative molecules from those merely cross-reactive, pursuit of patient's treatable traits addressing genetic, phenotypic, and psychosocial features, and omics, such as proteomics, epi-genomics, metabolomics, and breathomics, to forecast patient's responsiveness to therapies, to detect biomarker and mediators, and to verify the disease control. This new approach has already improved the precision of allergy diagnosis and is likely to significantly increase, through the higher performance achieved with the personalized treatment, the effectiveness of allergen immunotherapy by enhancing its already known and unique characteristics of treatment that acts on the causes.

引用

页码：1041 / 1052

页数：12

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