Successful Treatment of Idiopathic Recurrent Pericarditis in Children With Interleukin-1β Receptor Antagonist (Anakinra) An Unrecognized Autoinflammatory Disease?

被引：123

作者：

Picco, Paolo ^{[1
,2
]}

Brisca, Giacomo ^{[2
]}

Traverso, Francesco ^{[2
]}

Loy, Anna ^{[2
]}

Gattorno, Marco ^{[2
]}

Martini, Alberto ^{[2
]}

机构：

[1] Ist Giannina Gaslini, UO Pediat 2, I-16145 Genoa, Italy

[2] Univ Genoa, Genoa, Italy

来源：

ARTHRITIS AND RHEUMATISM | 2009年 / 60卷 / 01期

关键词：

FAMILIAL MEDITERRANEAN FEVER; COLCHICINE; PATIENT;

D O I：

10.1002/art.24174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recurrent pericarditis occurs in association with various medical conditions, but in most cases the condition appears to be idiopathic. Although high-dose steroid treatment is often effective, it may have serious side effects. Herein we describe 3 children with recurrent pericarditis who were treated at our hospital, during flares, with the interieukin-1 beta receptor antagonist anakinra, with immediate response. Pericarditis recurred when anakinra treatment was discontinued, and no further episodes occurred after it was resumed. Idiopathic recurrent pericarditis shares several features with autoinflammatory diseases, and anakinra has been efficacious in the treatment of the latter diseases. The findings in these patients suggest that idiopathic recurrent pericarditis may be a previously unrecognized autoinflammatory disease.

引用

页码：264 / 268

页数：5

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