MicroRNAs and other non-coding RNAs as targets for anticancer drug development

被引：1223

作者：

Ling, Hui ^{[1
]}

Fabbri, Muller ^{[2
,3
]}

Calin, George A. ^{[1
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Expt Therapeut & Leukemia Dept, Houston, TX 77030 USA

[2] Univ So Calif, Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Keck Sch Med,Saban Res Inst,Dept Pediat, Los Angeles, CA 90027 USA

[3] Univ So Calif, Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Keck Sch Med,Saban Res Inst,Dept Mol Microbiol &, Los Angeles, CA 90027 USA

[4] Univ Texas MD Anderson Canc Ctr, RNA Interference & Noncoding RNA Ctr, Houston, TX 77030 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2013年 / 12卷 / 11期

基金：

美国国家卫生研究院;

关键词：

NATURAL ANTISENSE TRANSCRIPTS; TUMOR-SUPPRESSOR GENE; IN-VIVO; MESSENGER-RNAS; LUNG-CANCER; MIR-17-SIMILAR-TO-92; CLUSTER; MIR-15A OLIGONUCLEOTIDES; METASTATIC PROGRESSION; CIRCULATING MICRORNAS; LYMPHOCYTIC-LEUKEMIA;

D O I：

10.1038/nrd4140

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The first cancer-targeted microRNA (miRNA) drug - MRX34, a liposome-based miR-34 mimic - entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in April 2013, and miRNA therapeutics are attracting special attention from both academia and biotechnology companies. Although miRNAs are the most studied non-coding RNAs (ncRNAs) to date, the importance of long non-coding RNAs (lncRNAs) is increasingly being recognized. Here, we summarize the roles of miRNAs and lncRNAs in cancer, with a focus on the recently identified novel mechanisms of action, and discuss the current strategies in designing ncRNA-targeting therapeutics, as well as the associated challenges.

引用

页码：847 / 865

页数：19

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